The Value of Oxygenation Saturation Index in Predicting the Outcomes of Patients with Acute Respiratory Distress Syndrome
Abstract
1. Introduction
2. Patients and Methods
2.1. Patients and Hospital Setting
2.2. Variables Measurements
2.3. Definitions
2.4. Statistical Analysis
3. Results
4. Discussion
Author Contributions
Conflicts of Interest
References
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Variables | No (%) of Patients (n = 101) | No (%) of Survivors (n = 43) | No (%) of Mortalities (n = 58) | p Value * |
---|---|---|---|---|
Age (years) | 69.2 ± 13.5 | 66.7 ± 14.4 | 71.0 ± 12.7 | 0.12 |
Gender | ||||
Male | 63 (62.4) | 25 (58.1) | 38 (65.5) | 0.45 |
Female | 38 (37.6) | 18 (41.9) | 20 (34.5) | |
APACHE II scores | 27.9 ± 10.4 | 23.0 ± 9.1 | 31.6 ± 9.8 | <0.001 |
Extra-pulmonary ARDS | 8 (7.9) | 3 (7.0) | 5 (8.6) | 0.76 |
Cause of ARDS | ||||
Pneumonia | 94 (94.1) | 40 (93.0) | 54 (93.1) | 0.29 |
Sepsis | 5 (5.0) | 1 (2.3) | 4 (6.9) | |
Major trauma | 1 (1.0) | 1 (2.3) | 0 (0) | |
Acute pancreatitis | 1 (1.0) | 1 (2.3) | 0 (0) | |
Shock | 81 (80.2) | 32 (74.4) | 49 (84.5) | 0.21 |
Underlying disease | ||||
Chronic lung disease | 5 (5.0) | 1 (2.3) | 4 (6.9) | 0.30 |
Chronic kidney disease | 21 (20.8) | 10 (23.3) | 11 (19.0) | 0.60 |
Congestive heart failure | 8 (7.9) | 2 (4.7) | 6 (10.3) | 0.30 |
Liver cirrhosis | 11 (10.9) | 5 (11.6) | 6 (10.3) | 0.84 |
Diabetes mellitus | 33 (32.7) | 15 (34.9) | 18 (31.0) | 0.68 |
Malignancy | 42 (41.6) | 15 (34.9) | 27 (46.6) | 0.24 |
Ventilator setting | ||||
PEEP | 10 (10–12) | 10 (10–12) | 10 (10–12) | 0.47 |
Vt | 450 (410–549) | 476 (420–557) | 450 (400–534) | 0.13 |
Laboratory findings | ||||
Hemoglobin | 9.9 (8.8–11.4) | 9.9 (9.7–17.2) | 9.9 (9.2–10.9) | 0.96 |
Total-bilirubin | 1.0 (0.5–2.0) | 0.8 (0.5–1.6) | 1.1 (0.6–2.4) | 0.16 |
pH | 7.35 (7.28–7.41) | 7.35 (7.28–7.41) | 7.34 (7.28–7.42) | 0.98 |
HCO3− | 20.3 (16.9–24.1) | 20.3 (17.0–22.5) | 20.0 (16.4–26.1) | 0.91 |
Lowest PaO2 | 72.0 (64.2–83.1) | 72.2 (64.3–83.2) | 71.7 (63.4–83.4) | 0.71 |
Lowest SpO2 | 90.0 (85.5–92.5) | 92.0 (90.0–94.0) | 88.0 (80.8–91.3) | <0.001 |
Lowest PaO2/FiO2 ratio | 108.8 (91.7–138.3) | 114.0 (100.9–145.6) | 106.0 (88.7–130.0) | 0.08 |
Lowest SpO2/FiO2 ratio | 145.0 (116.3–186.0) | 148.3 (130.7–190.0) | 139.3 (102.1–163.5) | 0.046 |
Highest mean airway pressure | 21.0 (19.5–23.0) | 21.0 (18.0–22.0) | 21.5 (20.0–24.0) | 0.012 |
Oxygenation index | 19.0 (15.0–23.5) | 15.9 (13.7–22.1) | 20.5 (16.0–26.6) | 0.008 |
Oxygenation saturation index | 15.0 (11.3–18.2) | 13.6 (9.7–17.2) | 16.0 (12.9–21.4) | 0.008 |
Outcome | ||||
MV duration | 12.0 (5–21.8) | 15.5 (8.8–32.5) | 8.0 (3.4–19.0) | 0.002 |
ICU LOS | 13.0 (4.3–25.8) | 19.0 (10.8–38) | 7.0 (2.8–18.0) | <0.001 |
Hospital LOS | 18.0 (4.3–33.3) | 32.5 (19.5–48.5) | 7.0 (2.8–18.0) | <0.001 |
Measure | Area under the ROC Curve | 95% CI | p Value |
---|---|---|---|
Lowest PaO2/FiO2 ratio | 0.603 | 0.492–0.714 | 0.08 |
Lowest SpO2/FiO2 ratio | 0.616 | 0.506–0.726 | 0.046 |
Oxygenation index | 0.654 | 0.547–0.761 | 0.008 |
Oxygen saturation index | 0.656 | 0.548–0.763 | 0.008 |
Variable | OR | 95% CI | p Value |
---|---|---|---|
Lowest PaO2/FiO2 ratio | |||
≤100 | 1 | ||
>100 | 0.794 | 0.25–2.52 | 0.7 |
Lowest SpO2/FiO2 ratio | |||
≤142 | 1 | ||
>142 | 0.36 | 0.09–1.35 | 0.13 |
Oxygenation index | |||
<16 | 1 | ||
≥16 | 2.92 | 0.98–8.68 | 0.054 |
Oxygenation saturation index | |||
<12 | 1 | ||
≥12 | 5.22 | 1.31–20.76 | 0.019 |
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Chen, W.-L.; Lin, W.-T.; Kung, S.-C.; Lai, C.-C.; Chao, C.-M. The Value of Oxygenation Saturation Index in Predicting the Outcomes of Patients with Acute Respiratory Distress Syndrome. J. Clin. Med. 2018, 7, 205. https://doi.org/10.3390/jcm7080205
Chen W-L, Lin W-T, Kung S-C, Lai C-C, Chao C-M. The Value of Oxygenation Saturation Index in Predicting the Outcomes of Patients with Acute Respiratory Distress Syndrome. Journal of Clinical Medicine. 2018; 7(8):205. https://doi.org/10.3390/jcm7080205
Chicago/Turabian StyleChen, Wan-Ling, Wei-Ting Lin, Shu-Chen Kung, Chih-Cheng Lai, and Chien-Ming Chao. 2018. "The Value of Oxygenation Saturation Index in Predicting the Outcomes of Patients with Acute Respiratory Distress Syndrome" Journal of Clinical Medicine 7, no. 8: 205. https://doi.org/10.3390/jcm7080205
APA StyleChen, W.-L., Lin, W.-T., Kung, S.-C., Lai, C.-C., & Chao, C.-M. (2018). The Value of Oxygenation Saturation Index in Predicting the Outcomes of Patients with Acute Respiratory Distress Syndrome. Journal of Clinical Medicine, 7(8), 205. https://doi.org/10.3390/jcm7080205