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Platelet-Rich Plasma May Offer a New Hope in Suppressed Wound Healing When Compared to Mesenchymal Stem Cells

1
Department of General Surgery, School of Medicine, Kirikkale University, 71450 Kirikkale, Turkey
2
Department of Pathology, School of Medicine, Kirikkale University, 71450 Kirikkale, Turkey
3
Department of Medical Biochemistry, Cerrahpaşa Medical Faculty, İstanbul University, 34452 Istanbul, Turkey
4
Department of General Surgery, Çorum Alaca State Hospital, 19600 Çorum, Turkey
5
Department of Anesthesiology and Reanimation, Kirikkale University, School of Medicine, 71450 Kirikkale, Turkey
6
Department of General Surgery, School of Medicine, Hitit University, 19030 Çorum, Turkey
7
Department of Cardiovascular Surgery, Bartin State Hospital, 74100 Bartin, Turkey
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(6), 143; https://doi.org/10.3390/jcm7060143
Received: 9 May 2018 / Revised: 30 May 2018 / Accepted: 6 June 2018 / Published: 8 June 2018
(This article belongs to the Section Hematology)
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Abstract

Background: The present study investigated the effectiveness of platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) in wound healing suppressed by corticosteroid in rats. Methods: Forty rats were separated into four groups. To disrupt the wound-healing processes, intraperitoneal single dose 10 mg/kg methylprednisolone was administered to all rats with the exception of Sham-S group. Then, full-thickness incision was performed to the abdominal skin of all animals, and PRP or MSCs were applied to the incision line except the Sham-S and Sham-M group animals. Ten days later, all animals were sacrificed to investigate: tissue collagenization, inflammation, and re-epithelialization grades histopathologically; and tissue hydroxyproline (HP), interleukin-1β (IL-1β), tumor necrosis factor-α levels biochemically. Results: Collagenization (p = 0.003) and inflammation grade (p = 0.002) values were higher in PR group. Tissue HP level value was found to be high in MC group (p < 0.001). Tissue IL-1β level value of Sham-M group was lower than those of other groups (p < 0.001). Conclusions: This preliminary study revealed that PRP could improve the histopathological grades in wound healing which was suppressed by corticosteroid in rats, while MSCs could show their therapeutic effects via biochemical route. These positive effects were more salient in PR group. View Full-Text
Keywords: platelet-rich plasma; mesenchymal stem cell; wound healing platelet-rich plasma; mesenchymal stem cell; wound healing
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Aydin, O.; Karaca, G.; Pehlivanli, F.; Altunkaya, C.; Uzun, H.; Özden, H.; Aydin, G.; Şahiner, İ.T.; Niyaz, M.; Güler, O. Platelet-Rich Plasma May Offer a New Hope in Suppressed Wound Healing When Compared to Mesenchymal Stem Cells. J. Clin. Med. 2018, 7, 143.

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