Next Article in Journal
Evaluation of the Effect of Oral Pyridostigmine on the Ileus after Abdominal Surgery: A Blinded Randomized Clinical Trial
Previous Article in Journal
The Relationship between Sleep Problems, Neurobiological Alterations, Core Symptoms of Autism Spectrum Disorder, and Psychiatric Comorbidities
Open AccessArticle

The Gender Impact on Morphogenetic Variability in Coronary Artery Disease: A Preliminary Study

1
Faculty of Medicine, University of Belgrade, Koste Todorovic 8, Belgrade 11000, Serbia
2
Department of Anesthesiology and Intensive Care, Clinic for Cardiac Surgery, Clinical Center of Serbia, Belgrade 11000, Serbia
3
Clinic for Cardiology, Clinical Center of Serbia, Belgrade 11000, Serbia
4
Institute for Human Genetics, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia
5
Clinic for Cardiac Surgery, Clinical Center of Serbia, Belgrade 11000, Serbia
6
Clinic for Vascular and Endovascular Surgery, Clinical Center of Serbia, Belgrade 11000, Serbia
7
Department of Physical Medicine and Rehabilitation, University Children’s Hospital, Belgrade 11000, Serbia
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(5), 103; https://doi.org/10.3390/jcm7050103
Received: 16 April 2018 / Revised: 27 April 2018 / Accepted: 30 April 2018 / Published: 3 May 2018
(This article belongs to the Section Vascular Medicine)
We analyzed morphogenetic variability and degree of genetic homozygosity in male and female individuals with coronary artery disease (CAD) versus unaffected controls. We have tested 235 CAD patients; 109 were diagnosed also with diabetes mellitus (DM) and 126 with hypertension (HTN). We additionally evaluated 152 healthy individuals without manifested CAD. For the evaluation of the degree of recessive homozygosity, we have performed the homozygously recessive characteristics (HRC) test and tested 19 HRCs. In controls, the frequency of HRC for males was 2.88 ± 1.89, while for females, it was 3.65 ± 1.60. In the CAD group, the frequency of HRC for males was 4.21 ± 1.47, while for females, it was 4.73 ± 1.60. There is significant difference in HRC frequencies between controls and CAD separately for males (p < 0.001) and females (p < 0.001). The same applies between controls and CAD with DM (males: p < 0.001 and females: p = 0.004), and controls and CAD with HTN (males: p < 0.001 and females: p < 0.001). There is no significant difference in HRC frequencies between the group of CAD with DM and the group of CAD with HTN (males: p = 0.952 and females: p = 0.529). Our findings point to the increased degree of recessive homozygosity and decreased variability in both genders of CAD patients versus controls, indicating the potential genetic predisposition for CAD. View Full-Text
Keywords: coronary artery disease; homozygous recessive characteristics; variability; gender coronary artery disease; homozygous recessive characteristics; variability; gender
Show Figures

Figure 1

MDPI and ACS Style

Karan, R.; Obrenovic-Kircanski, B.; Cvjeticanin, S.; Kovacevic-Kostic, N.; Velinovic, M.; Milicevic, V.; Vranes-Stoimirov, M.; Nikolic, D. The Gender Impact on Morphogenetic Variability in Coronary Artery Disease: A Preliminary Study. J. Clin. Med. 2018, 7, 103.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop