Next Article in Journal
Bone Metabolism Markers and Bone Mineral Density in Patients on Long-Term Acenocoumarol Treatment: A Cross-Sectional Study
Previous Article in Journal
Epidemiology and Prognostic Importance of Atrial Fibrillation in Kidney Transplant Recipients: A Meta-Analysis
Open AccessConcept Paper

The Vagus Nerve Can Predict and Possibly Modulate Non-Communicable Chronic Diseases: Introducing a Neuroimmunological Paradigm to Public Health

1
SCALAB UMR CNRS 9193, Université Lille, BP 60149, Villeneuve d’Ascq CEDEX 59653, France
2
Mental Health and Wellbeing Research Group, Vrije Universiteit Brussel (VUB), Laerbeeklaan 103, 1090 Jette, Brussels, Belgium
3
Faculty of Health Care, University College Odisee, 9302 Aalst, Belgium
4
Department of Neuroscience and Psychology, College of Medicine, Ohio State University, 33 Psychology Building, 1835 Neil Ave. Columbus, OH 43210, USA
5
Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), Laerbeeklaan 103, 1090 Jette, Brussels, Belgium
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(10), 371; https://doi.org/10.3390/jcm7100371
Received: 19 September 2018 / Revised: 10 October 2018 / Accepted: 15 October 2018 / Published: 19 October 2018
(This article belongs to the Section Epidemiology & Public Health)
  |  
PDF [4057 KB, uploaded 19 October 2018]
  |  

Abstract

Global burden of diseases (GBD) includes non-communicable conditions such as cardiovascular diseases, cancer and chronic obstructive pulmonary disease. These share important behavioral risk factors (e.g., smoking, diet) and pathophysiological contributing factors (oxidative stress, inflammation and excessive sympathetic activity). This article wishes to introduce to medicine and public health a new paradigm to predict, understand, prevent and possibly treat such diseases based on the science of neuro-immunology and specifically by focusing on vagal neuro-modulation. Vagal nerve activity is related to frontal brain activity which regulates unhealthy lifestyle behaviors. Epidemiologically, high vagal activity, indexed by greater heart rate variability (HRV), independently predicts reduced risk of GBD and better prognosis in GBD. Biologically, the vagus nerve inhibits oxidative stress, inflammation and sympathetic activity (and associated hypoxia). Finally, current non-invasive methods exist to activate this nerve for neuro-modulation, and have promising clinical effects. Indeed, preliminary evidence exists for the beneficial effects of vagal nerve activation in diabetes, stroke, myocardial infarction and possibly cancer. Thus, we propose to routinely implement measurement of HRV to predict such GBD in populations, and to test in randomized controlled trials effects of non-invasive vagal nerve activation on prevention and treatment of GBD, reflecting possible neuro-modulation of health. View Full-Text
Keywords: global burden of diseases; neuroimmunology; neuromodulation; vagal nerve; prediction; prevention global burden of diseases; neuroimmunology; neuromodulation; vagal nerve; prediction; prevention
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Gidron, Y.; Deschepper, R.; De Couck, M.; Thayer, J.F.; Velkeniers, B. The Vagus Nerve Can Predict and Possibly Modulate Non-Communicable Chronic Diseases: Introducing a Neuroimmunological Paradigm to Public Health. J. Clin. Med. 2018, 7, 371.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top