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J. Clin. Med. 2015, 4(5), 832-846;

Advancements in Pharmacotherapy for Noncancerous Manifestations of HPV

Center for Clinical Studies, Houston 77004, TX, USA
Department of Dermatology, the University of Texas Health Science Center at Houston, Houston 77030, TX, USA
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Jane Grant-Kels
Received: 1 December 2014 / Revised: 7 April 2015 / Accepted: 14 April 2015 / Published: 24 April 2015
(This article belongs to the Special Issue Clinical Advances of Human Papillomaviruses)
Full-Text   |   PDF [174 KB, uploaded 24 April 2015]


Human papillomavirus (HPV) is the most common sexually transmitted disease. Via infection of the basal epithelial cells, HPV causes numerous malignancies and noncancerous cutaneous manifestations. Noncancerous cutaneous manifestations of HPV, including common, plantar, plane, and anogenital warts, are among the most common reasons for an office visit. Although there are various therapies available, they are notoriously difficult to treat. HPV treatments can be grouped into destructive (cantharidin, salicylic acid), virucidal (cidofovir, interferon-α), antimitotic (bleomycin, podophyllotoxin, 5-fluorouracil), immunotherapy (Candida antigen, contact allergen immunotherapy, imiquimod) or miscellaneous (trichloroacetic acid, polyphenon E). The mechanism of action, recent efficacy data, safety profile and recommended regimen for each of these treatment modalities is discussed. View Full-Text
Keywords: pharmacotherapy; HPV; warts; condyloma; treatment pharmacotherapy; HPV; warts; condyloma; treatment
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Kollipara, R.; Ekhlassi, E.; Downing, C.; Guidry, J.; Lee, M.; Tyring, S.K. Advancements in Pharmacotherapy for Noncancerous Manifestations of HPV. J. Clin. Med. 2015, 4, 832-846.

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