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Open AccessCase Report
J. Clin. Med. 2013, 2(3), 45-48;

Recurrent Fever of Unknown Origin (FUO) Due to Periodic Fever, Aphthous Stomatititis, Pharyngitis and Adenitis (FAPA) Syndrome in an Adult

Infectious Disease Division, Winthrop-University Hospital, Mineola, New York, NY 11501, USA
School of Medicine, State University of New York, Stony Brook, New York, NY 11794, USA
Author to whom correspondence should be addressed.
Received: 20 July 2013 / Revised: 30 July 2013 / Accepted: 6 August 2013 / Published: 19 August 2013
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FAPA syndrome (periodic fever, aphthous stomatititis, pharyngitis and adenitis) is a relatively new entity described in pediatric patients. In adults, reports of FAPA are limited to rare case reports. The differential diagnosis of FAPA in adults includes Behcet’s syndrome, familial Mediterranean fever (FMF), Hyper IgD syndrome and juvenile rheumatoid arthritis (JRA), i.e., adult Still’s disease. With FAPA syndrome, between episodes patients are completely asymptomatic and serologic inflammatory markers such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and white blood cell (WBC) count are normal. The etiology of FAFA is unknown, but lack of secondary cases or clustering in close contacts, lack of seasonality, and the lack of progression for years argue against an infectious etiology. We describe an extremely rare case of an adult with a recurrent FUO with profuse night sweats and prominent chills due to FAPA syndrome. View Full-Text
Keywords: adult FAPA syndrome; recurrent FUO adult FAPA syndrome; recurrent FUO
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Muñoz-Gómez, S.; Cunha, B.A. Recurrent Fever of Unknown Origin (FUO) Due to Periodic Fever, Aphthous Stomatititis, Pharyngitis and Adenitis (FAPA) Syndrome in an Adult. J. Clin. Med. 2013, 2, 45-48.

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