Unraveling the Skin Microbiome in Hidradenitis Suppurativa: Implications for Treatment and Disease Progression
Abstract
:1. Introduction
2. Results
- A.
- Samples collected from superficial HS lesions
- Samples collected from superficial lesions located in the axillary region
- 2.
- Samples collected from superficial lesions located in the inguinal and gluteal regions
- 3.
- Samples collected from superficial lesions located in face and neck region
- B.
- Samples collected from deep HS lesions
- Samples collected from deep HS lesions located in the axillary region
- 2.
- Samples collected from deep HS lesions located in the inguinal and gluteal regions
- 3.
- Samples collected from deep HS lesions in the face and neck region
- C.
- Antibiotic resistance profile of bacterial strains isolated from HS lesions
3. Discussion
4. Materials and Methods
5. Limitations
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
HS | Hidradenitis suppurativa |
BMI | Body mass index |
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Bacterial Strains Isolated from Superficial HS Lesions | Total | Female Patients | Male Patients |
---|---|---|---|
Staphylococcus epidermidis | 14 | 1 | 13 |
Staphylococcus aureus | 10 | 1 | 9 |
Staphylococcus lugdunensis | 9 | 4 | 5 |
Peptoniphilus spp | 6 | 1 | 5 |
Enterococcus faecalis | 5 | 2 | 3 |
Proteus mirabilis | 4 | 1 | 3 |
Staphylococcus haemolyticus | 4 | 2 | 2 |
Porphyromonas asaccharolytica | 3 | 2 | 1 |
Streptococcus agalactiae | 3 | 2 | 1 |
Actinotignum scaalii | 2 | 0 | 2 |
Campylobacter ureolyticus | 2 | 0 | 2 |
Cutibacterium acnes | 2 | 1 | 1 |
Cutibacterium avidum | 2 | 1 | 1 |
Dialister micraerophilus | 2 | 0 | 2 |
Fannyhessea vaginae | 2 | 0 | 2 |
Fusobacterium gonidiaformans | 2 | 1 | 1 |
Mobiluncus curtisii | 2 | 0 | 2 |
Parvimonas micra | 2 | 1 | 1 |
Porphyromonas uenonis | 2 | 0 | 2 |
Prevotella bivia | 2 | 0 | 2 |
Prevotella timonensis | 2 | 2 | 0 |
Coagulase negative staphilococci | 2 | 1 | 1 |
Staphylococcus hominis | 2 | 0 | 2 |
Corynebacterium tuberculostearicum | 2 | 0 | 2 |
Acinetobacter nosocomialis | 1 | 0 | 1 |
Actinomyces | 1 | 0 | 1 |
Anaerococcus degeneri | 1 | 0 | 1 |
Anaerococcus obesiensis | 1 | 0 | 1 |
Anaerococcus vaginalis | 1 | 0 | 1 |
Bacteroides coagulans | 1 | 0 | 1 |
Bulleidia extructa | 1 | 0 | 1 |
Corynebacterium amycolatum | 1 | 0 | 1 |
Corynebacterium aurimucosum | 1 | 0 | 1 |
Corynebacterium coyleae | 1 | 0 | 1 |
Corynebacterium striatum | 1 | 0 | 1 |
Corynebacterium simulans | 1 | 0 | 1 |
Escherichia coli | 1 | 0 | 1 |
Fenollaria massiliensis | 1 | 0 | 1 |
Finegoldia magna | 1 | 0 | 1 |
Gleimia europae | 1 | 1 | 0 |
Klebisella pneumoniae | 1 | 0 | 1 |
Klebsiella oxytoca | 1 | 0 | 1 |
Kylococcus | 1 | 0 | 1 |
Peptoniphilus grossensis | 1 | 0 | 1 |
Peptoniphilus harei | 1 | 0 | 1 |
Peptoniphilus lacrimalis | 1 | 0 | 1 |
Peptostreptococcus niger | 1 | 0 | 1 |
Porphyromonas somerae | 1 | 0 | 1 |
Staphylococcus saccharolyticus | 1 | 1 | 0 |
Staphylococcus warneri | 1 | 1 | 0 |
Schaalia funkei | 1 | 1 | 0 |
Schaalia turcensis | 1 | 0 | 1 |
Solobacterium moorei | 1 | 0 | 1 |
Group C streptococcus | 1 | 0 | 1 |
Peptostreptococcus anaerobius | 1 | 1 | 0 |
Total | 120 | 28 | 92 |
Bacterial Strains Isolated from Deep HS Lesions | Total | Female Patients | Male Patients |
---|---|---|---|
Staphylococcus epidermidis | 11 | 1 | 10 |
Staphylococcus aureus | 7 | 0 | 7 |
Corynebacterium tuberculostearicum | 6 | 0 | 6 |
Fenollaria massiliensis | 3 | 0 | 3 |
Staphylococcus lugdunensis | 3 | 3 | 0 |
Actinomyces turicensis | 2 | 0 | 2 |
Actinotignum schaalii | 2 | 2 | 0 |
Corynebacterium amycolatum | 2 | 0 | 2 |
Corynebacterium striatum | 2 | 0 | 2 |
Campylobacter ureolyticus | 2 | 1 | 1 |
Dialister micraerophilus | 2 | 0 | 2 |
Fusobacterium gonidiaformans | 2 | 0 | 2 |
Klebsiella pneumoniae | 2 | 0 | 2 |
Proteus mirabilis | 2 | 0 | 2 |
Propionibacterium spp. | 2 | 1 | 1 |
Coagulase negative staphylococci | 2 | 1 | 1 |
Staphylococcus haemolyticus | 2 | 0 | 2 |
Streptococcus constellatus | 2 | 0 | 2 |
Actinobaculum massiliense | 1 | 1 | 0 |
Actinomyces europaeus | 1 | 0 | 1 |
Anaerococcus vaginalis | 1 | 0 | 1 |
Bacteroides ovatus | 1 | 0 | 1 |
Cutibacterium acnes | 1 | 0 | 1 |
Dialister micraerophilus | 1 | 1 | 0 |
Enterococcus faecalis | 1 | 1 | 0 |
Fannyhessea vaginae | 1 | 0 | 1 |
Lactobacillus paracasei | 1 | 1 | 0 |
Mobiluncus curtisii | 1 | 0 | 1 |
Parvimonas micra | 1 | 0 | 1 |
Peptococcus niger | 1 | 0 | 1 |
Peptoniphilus indolicus | 1 | 0 | 1 |
Peptoniphilus lacrimalis | 1 | 0 | 1 |
Peptostreptococcus anaerobius | 1 | 0 | 1 |
Porphyromonas asaccharolytica | 1 | 0 | 1 |
Porphyromonas somerae | 1 | 1 | 0 |
Prevotella disiens | 1 | 1 | 0 |
Staphylococcus hominis | 1 | 0 | 1 |
Staphylococcus warneri | 1 | 0 | 1 |
Slackia exigua | 1 | 1 | 0 |
Streptococcus agalactiae | 1 | 0 | 1 |
Streptococcus anginosus | 1 | 0 | 1 |
Finegoldia magna | 2 | 2 | 0 |
Total | 81 | 18 | 63 |
Bacterial Strain | Antibiotic Resistance |
---|---|
Actinotignum schaalii | Metronidazole |
Enterococcus faecalis | Doxycycline |
Escherichia coli | Ampicillin, Levofloxacin, Co-trimoxazole |
Finegoldia magna | Clindamycin |
Klebsiella pneumoniae | Co-trimoxazole |
Propionibacterium spp. | Metronidazole |
Proteus mirabilis | Gentamicin |
Staphylococcus aureus | Penicillin |
Staphylococcus aureus | Penicillin |
Staphylococcus aureus-MRSA | Oxacillin, Erythromycin, Clindamycin |
Staphylococcus aureus | Oxacillin, Erythromycin, Clindamycin |
Staphylococcus aureus-MRSA, MLSBi | Penicillin, Oxacillin, Erythromycin, Clindamycin, Tetracycline |
Coagulase negative staphylococcus | Penicillin, Erythromycin, Clindamycin |
Coagulase negative staphylococcus | Penicillin, Erythromycin, Clindamycin, Tetracycline |
Coagulase negative staphylococcus | Penicillin, Oxacillin, Tetracycline |
Staphylococcus lugdunensis | Penicillin, Erythromycin, Clindamycin |
Staphylococcus lugdunensis | Penicillin |
Group B streptococcus | Erythromycin, Clindamicyne, Doxycycline |
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Cucu, C.I.; Giurcăneanu, C.; Mihai, M.M.; Andronic, T.; Ancuta, I.; Popa, M.I.; Macovei, I.S.; Popa, L.G. Unraveling the Skin Microbiome in Hidradenitis Suppurativa: Implications for Treatment and Disease Progression. J. Clin. Med. 2025, 14, 2424. https://doi.org/10.3390/jcm14072424
Cucu CI, Giurcăneanu C, Mihai MM, Andronic T, Ancuta I, Popa MI, Macovei IS, Popa LG. Unraveling the Skin Microbiome in Hidradenitis Suppurativa: Implications for Treatment and Disease Progression. Journal of Clinical Medicine. 2025; 14(7):2424. https://doi.org/10.3390/jcm14072424
Chicago/Turabian StyleCucu, Corina Ioana, Călin Giurcăneanu, Mara Madalina Mihai, Teodora Andronic, Ioan Ancuta, Mircea Ioan Popa, Ioana Sabina Macovei, and Liliana Gabriela Popa. 2025. "Unraveling the Skin Microbiome in Hidradenitis Suppurativa: Implications for Treatment and Disease Progression" Journal of Clinical Medicine 14, no. 7: 2424. https://doi.org/10.3390/jcm14072424
APA StyleCucu, C. I., Giurcăneanu, C., Mihai, M. M., Andronic, T., Ancuta, I., Popa, M. I., Macovei, I. S., & Popa, L. G. (2025). Unraveling the Skin Microbiome in Hidradenitis Suppurativa: Implications for Treatment and Disease Progression. Journal of Clinical Medicine, 14(7), 2424. https://doi.org/10.3390/jcm14072424