Advancing Non-Invasive Ophthalmic Imaging in Sturge–Weber Syndrome: Clinical Guidelines Towards Early Choroidal Hemangioma Detection
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
Limitations of the Study
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Patient Number | Age | Sex | Leptomeningeal Angioma | Nevus Flammeus | Glaucoma | BCVA (ETDRS Charts) | IOP RE/LE | Enrolled | |
---|---|---|---|---|---|---|---|---|---|
RE | LE | ||||||||
1 | 27 | F | YES | YES (LE) | YES (LE) | 25 | 0 | 12/13 | YES |
2 | 16 | M | YES | YES (LE) | YES (LE) | 47 | 48 | 14/10 | YES |
3 | 42 | F | NO | YES (RE) | YES (RE) | 0 | 57 | 20/12 | YES |
4 | 20 | M | NO | YES (RE) | YES (RE) | 27 | 51 | 18/16 | YES |
5 | 48 | F | YES | YES (RE) | YES (RE) | 52 | 55 | 17/14 | YES |
6 | 13 | F | YES | YES (RE) | YES (RE) | NA | NA | NA | NO |
7 | 19 | M | NO | YES (RE) | YES (RE) | 48 | 51 | 20/16 | YES |
8 | 4 | M | YES | YES (RE) | NO | 55 | 55 | 12/12 | YES |
9 | 7 | M | YES | YES (RE) | YES (RE) | 0 | 35 | 14/16 | YES |
10 | 17 | F | YES | YES (RE) | YES (RE) | 0 | 35 | 14/16 | YES |
11 | 38 | F | YES | YES (LE) | NO | 55 | 50 | 10/17 | YES |
12 | 20 | F | NO | YES | YES | 5 | 53 | 18/14 | YES |
13 | 68 | M | NO | YES (LE) | YES (LE) | 55 | 0 | 14/20 | YES |
14 | 4 | F | YES | YES (RE) | NO | NA | NA | 12/12 | YES |
15 | 57 | F | NO | YES (LE) | NO | 55 | 55 | 14/14 | YES |
16 | 62 | F | NO | YES (RE) | NO | 55 | 55 | 14/14 | YES |
17 | 11 | M | YES | YES (RE) | NO | 53 | 55 | 18/18 | YES |
Patient Number | Diagnosis Through Fundus Photography | Fundus Photography Findings | Diagnosis Through SDOCT | SDOCT Findings | Diagnosis Through NIR | NIR Findings |
---|---|---|---|---|---|---|
1 | NO, poor quality imaging | NA | YES | LE: hyporreflective choroidal lesion associated with paralesional choroidal folds | NO, poor quality imaging | demarcation line |
2 | YES | chorioretinal folds, no tessellation, arteriovenous crossing | YES | LE: hyporreflective choroidal lesion, inner retina folding, paralesional choroidal fold | NO | hyperreflective area/dots (temporal), vessel alterations |
3 | NO | RE chorioretinal folds | YES | RE: hyporreflective choroidal lesion, neuroepithelium detachment with associated subretinal fluid | YES | lacquer cracks, hypo-hyperreflectivity |
4 | NO | RE chorioretinal folds | YES | RE: hyporreflective choroidal lesion | NO | folds, diffuse hypo-hyperreflectivity |
5 | YES | no tessellation | YES | RE: choroidal thickening | NO | hyperreflective area/dots (temporal) |
6 | NA | NA | NA | NA | NA | NA |
7 | YES | no tessellation, vascular tortuosity, chorioretinal folds | YES | RE: hyporreflective choroidal lesion | YES | hyperreflective area/dots (temporal), vessel alterations |
8 | NO | NA | YES | RE: diffuse choroidal thickening | NO | hyperreflective area/dots (temporal) |
9 | YES | no tessellation, vascular tortuosity | YES | RE: diffuse choroidal thickening | NO | NA |
10 | YES | no tessellation, vascular tortuosity, drusen-like lesions, macular hyperpigmentation | YES | RE: diffuse choroidal thickening, pseudodrusen-like lesions. | YES | hyperreflective dots, vessel alterations |
11 | NO | normal | YES | LE: diffuse choroidal thickening | NO | normal |
12 | NO | vascular tortuosity | YES | LE: diffuse choroidal thickening | NO | hyperreflective dots |
13 | NO | no tessellation | NO | normal | NO | normal |
14 | NO | no tessellation | YES | RE: diffuse choroidal thickening | NO | normal |
15 | NO | no tessellation | YES | LE: diffuse choroidal thickening | NO | hyperreflective dots |
16 | NO | drusen-like lesion | YES | Bilateral: choroidal thickening | NO | hyperreflective dots |
17 | NO | no tessellation | YES | RE: diffuse choroidal thickening | NO | hyperreflective dots |
Choroidal Thickness (μm) in the DCH Affected Eye | Choroidal Thickness (μm) in the Fellow Eye | Choroidal Thickness (μm) Inter Eye Difference |
---|---|---|
NA | 341 | NA |
315 | 256 | 59 |
NA | 202 | NA |
709 | 452 | 257 |
517 | 135 | 382 |
NA | NA | NA |
NA | 367 | NA |
454 | 233 | 221 |
520 | 270 | 250 |
814 | 366 | 448 |
1060 | 520 | 540 |
472 | 359 | 113 |
NA | 345 | NA |
460 | 330 | 130 |
421 | 418 | 3 |
433 | 447 | −14 |
462 | 368 | 94 |
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Di Pippo, M.; Rullo, D.; Ciancimino, C.; Grassi, F.; Ferretti, A.; Parisi, P.; Di Nardo, G.; Orsini, A.; Perulli, M.; Battaglia, D.I.; et al. Advancing Non-Invasive Ophthalmic Imaging in Sturge–Weber Syndrome: Clinical Guidelines Towards Early Choroidal Hemangioma Detection. J. Clin. Med. 2025, 14, 7012. https://doi.org/10.3390/jcm14197012
Di Pippo M, Rullo D, Ciancimino C, Grassi F, Ferretti A, Parisi P, Di Nardo G, Orsini A, Perulli M, Battaglia DI, et al. Advancing Non-Invasive Ophthalmic Imaging in Sturge–Weber Syndrome: Clinical Guidelines Towards Early Choroidal Hemangioma Detection. Journal of Clinical Medicine. 2025; 14(19):7012. https://doi.org/10.3390/jcm14197012
Chicago/Turabian StyleDi Pippo, Mariachiara, Daria Rullo, Chiara Ciancimino, Flaminia Grassi, Alessandro Ferretti, Pasquale Parisi, Giovanni Di Nardo, Alessandro Orsini, Marco Perulli, Domenica Immacolata Battaglia, and et al. 2025. "Advancing Non-Invasive Ophthalmic Imaging in Sturge–Weber Syndrome: Clinical Guidelines Towards Early Choroidal Hemangioma Detection" Journal of Clinical Medicine 14, no. 19: 7012. https://doi.org/10.3390/jcm14197012
APA StyleDi Pippo, M., Rullo, D., Ciancimino, C., Grassi, F., Ferretti, A., Parisi, P., Di Nardo, G., Orsini, A., Perulli, M., Battaglia, D. I., Nicodemi, E. M., & Abdolrahimzadeh, S. (2025). Advancing Non-Invasive Ophthalmic Imaging in Sturge–Weber Syndrome: Clinical Guidelines Towards Early Choroidal Hemangioma Detection. Journal of Clinical Medicine, 14(19), 7012. https://doi.org/10.3390/jcm14197012