Nulliparas at Term with Premature Rupture of Membranes and an Unfavorable Cervix: Labor Induction with Prostaglandin or Oxytocin? A Retrospective Matched Case Study
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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PGE2 n = 95 | Oxytocin n = 95 | p Value | |
---|---|---|---|
Maternal age | 25.9 ± 4.7 | 26.7 ± 4.5 | 0.227 |
Gestational week | 38.6 ± 0.9 | 38.6 ± 0.9 | 0.707 |
Modified Bishop score ≤ 5 | 95 (100%) | 95 (100%) | 1.000 |
Cervical dilatation (cm) | 0.77 ± 0.6 | 1.04 ± 0.8 | 0.009 |
Modified Bishop score | 2.07 ± 1.3 | 2.64 ± 1.3 | 0.004 |
Time from PROM to IOL (hours) | 23.5 ± 19.2 | 24.3 ± 21.4 | 0.925 |
Vertex position occipital anterior | 93 (98%) | 94 (98.9%) | 0.500 |
Birth weight of newborn (grams) | 3109 ± 392 | 3101 ± 334 | 0.879 |
PGE2 n = 95 | Oxytocin n = 95 | p Value | |
---|---|---|---|
Time from IOL to full dilatation (hours) | 18.8± 9.5 | 16.5 ± 9.1 | 0.127 |
Length of second stage (hours) | 1.7± 1.1 | 1.6± 1.0 | 0.582 |
Time from IOL to delivery (hours) | 21.8± 10.0 | 18.5 ± 10.25 | 0.025 |
Mode of delivery | |||
Spontaneous vaginal delivery | 59 (62%) | 65 (68%) | 0.387 |
Assisted vaginal delivery | 19 (20%) | 12 (13%) | |
Cesarean delivery | 17 (18%) | 18 (19%) | |
Chorioamnionitis | 15 (16%) | 6 (6%) | 0.029 |
Blood transfusion | 3 (3%) | 2 (2%) | 0.505 |
Apgar score at ′ 5 ≤ 7 | 3 (3%) | 2 (2%) | 0.571 |
Admission to NICU ** | 1 (1%) | 4 (4%) | 0.187 |
PGE2 n = 65 | Oxytocin n = 65 | p Value | |
---|---|---|---|
Maternal age | 26.3 ± 4.8 | 26.8 ± 4.7 | 0. 477 |
Gestational week | 38.9 ± 0.9 | 38.9 ± 0.9 | 0.787 |
Cervical dilatation (cm) | 0.84 | 1.09 | 0.033 |
Modified Bishop score | 2.37 ± 1.4 | 2.35 ± 1.4 | 0.951 |
Time from PROM to IOL (hours) | 23.6 ± 20.6 | 24.5 ± 23.4 | 0.810 |
Vertex position occipital anterior | 65 (100%) | 64 (98.5%) | 0.500 |
Birth weight of newborn (grams) | 3127 ± 432 | 3122 ± 392 | 0.945 |
PGE2 n = 65 | Oxytocin n = 65 | p Value | |
---|---|---|---|
Time from IOL to full dilatation (hours) | 19.2 ± 9.9 | 16.4 ± 9.8 | 0.157 |
Time from IOL to delivery (hours) | 22.4 ± 10.5 | 17.9 ± 10.1 | 0.014 |
Mode of delivery | |||
Spontaneous vaginal delivery | 39 (60%) | 44 (68%) | 0.273 |
Assisted vaginal delivery | 15 (23%) | 8 (12%) | |
Cesarean delivery | 11 (17%) | 13 (20%) | |
Chorioamnionitis | 11 (17%) | 4 (6%) | 0.049 |
Blood transfusion | 3 (4.6%) | 2 (3%) | 0.505 |
Apgar score ′5 ≤ 7 | 2 (3%) | 2 (3%) | 0.721 |
Admission to NICU ** | 1 (1.5%) | 4 (6.2%) | 0.183 |
Study Primary Author (ref#) | Method of Study | Sample Size (Primiparous) | Primary Outcome | Result |
---|---|---|---|---|
Kulhan [5] | Retrospective Primiparous only Oxytocin versus PGE2 vaginal pessary, slow-release | 224 | Vaginal delivery within 24 h of labor induction | Oxytocin 72/112 (64.3%) vs. PGE2 53/112 (47.3%), p = 0.023 |
Güngördük [6] | RCT Mixed parity Oxytocin versus PGE2 pessary followed 6 h later by intravenous oxytocin infusion | 238 | Vaginal delivery within 24 h of labor induction | PGE2 72% vs. oxytocin 55%; relative risk, 1.30; 95% confidence interval, 1.07–1.59; p = 0.007) |
Feret [18] | Retrospective Primiparous only Oxytocin versus buccal misoprostol | 130 | Time from admission to delivery | Women receiving oxytocin had faster admission-to-delivery times than women receiving misoprostol (16.9 vs. 19.9 h, p = 0.013) |
Gulersen [19] | Retrospective Primiparous only Oxytocin versus PGE2 vaginal pessary, slow-release | 275 | Time interval from PROM to delivery/chorioamnionitis/neonatal intensive care unit (NICU) admissions | Time interval from PROM to delivery PGE2 24.4 vs. oxytocin 17.9 h; aHR 0.56, p ≤ 0.0001 Chorioamnionitis PGE2 18.1% vs. oxytocin 6.1%; aOR 4.14, p = 0.001 NICU PGE2 20.2% vs. oxytocin 9.9%; aOR 2.4, p = 0.02 |
Liu [20] | Retrospective, primiparous only, PGE2 pessary followed by oxytocin infusion versus oxytocin | 205 | Vaginal delivery within 12 h and total vaginal delivery | vaginal delivery within 12 h and total vaginal delivery were higher in the PGE2 group (28.4% vs. 7.8%, p = 0.0001; 79.4% vs. 62.1%, p = 0.009, respectively) |
Zhang [21] | Retrospective, mixed parity, oxytocin versus vaginal misoprostol | 515 | Vaginal delivery within 24 h of labor induction and cesarean delivery rate | More nulliparas in the misoprostol group achieved vaginal delivery within 24 h than in the oxytocin group (60.5% vs. 45.4%, p = 0.001), and there was a lower cesarean delivery rate (12.6% vs. 27.5%, p < 0.001) |
Bas. current study | Retrospective, matched cases and controls Primiparous only Oxytocin versus vaginal PGE2 gel | 190 | Time from induction to delivery/chorioamnionitis/ | Within 24 h delivered, PGE2 55(58%) compared to oxytocin 72 (76%), (p = 0.033) Chorioamnionitis PGE2 16% vs. oxytocin 6%, p = 0.029 |
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Bas Lando, M.; Majida, E.; Solnica, A.; Helman, S.; Margaliot Kalifa, T.; Grisaru-Granovsky, S.; Reichman, O. Nulliparas at Term with Premature Rupture of Membranes and an Unfavorable Cervix: Labor Induction with Prostaglandin or Oxytocin? A Retrospective Matched Case Study. J. Clin. Med. 2024, 13, 3384. https://doi.org/10.3390/jcm13123384
Bas Lando M, Majida E, Solnica A, Helman S, Margaliot Kalifa T, Grisaru-Granovsky S, Reichman O. Nulliparas at Term with Premature Rupture of Membranes and an Unfavorable Cervix: Labor Induction with Prostaglandin or Oxytocin? A Retrospective Matched Case Study. Journal of Clinical Medicine. 2024; 13(12):3384. https://doi.org/10.3390/jcm13123384
Chicago/Turabian StyleBas Lando, Maayan, Ewida Majida, Amy Solnica, Sarit Helman, Tal Margaliot Kalifa, Sorina Grisaru-Granovsky, and Orna Reichman. 2024. "Nulliparas at Term with Premature Rupture of Membranes and an Unfavorable Cervix: Labor Induction with Prostaglandin or Oxytocin? A Retrospective Matched Case Study" Journal of Clinical Medicine 13, no. 12: 3384. https://doi.org/10.3390/jcm13123384
APA StyleBas Lando, M., Majida, E., Solnica, A., Helman, S., Margaliot Kalifa, T., Grisaru-Granovsky, S., & Reichman, O. (2024). Nulliparas at Term with Premature Rupture of Membranes and an Unfavorable Cervix: Labor Induction with Prostaglandin or Oxytocin? A Retrospective Matched Case Study. Journal of Clinical Medicine, 13(12), 3384. https://doi.org/10.3390/jcm13123384