Clean Intermittent Catheterization in Children under 12 Years Does Not Have a Negative Impact on Long-Term Graft Survival following Pediatric Kidney Transplantation
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Causes of ESRD in Children <12 Years Old in Our Center | n = 44 |
---|---|
Posterior urethral valves (PUVs) | 13 (29.5%) |
Renal aplasia/hypoplasia/dysplasia | 7 (15.9%) |
Reflux nephropathy | 6 (13.6%) |
VACTERL association | 4 (9.0%) |
Focal segmental glomerulosclerosis (FSGS) | 2 (4.5%) |
Congenital nephrotic syndrome | 2 (4.5%) |
Hemolytic uremic syndrome | 2 (4.5%) |
Polycystic kidney disease | 2 (4.5%) |
Other (cystinosis, bilateral nephrectomy, etc.) | 6 |
Parameter | Control Group (No LUTD) n = 18 | LUTD CIC Group n = 8 | LUTD No CIC n = 15 | p |
---|---|---|---|---|
Organ donation | 0.013 | |||
Living donation | 0 | 2 | 0 | |
Postmortem donation | 18 | 6 | 15 | |
Recipient sex | 0.036 | |||
Male | 8 | 7 | 12 | |
Female | 10 | 1 | 3 | |
Age of the recipient (years; median (IQR)) | 7 (5–8) | 7 (4–10.5) | 6 (5–7) | 0.527 |
Age of the donor (years; median (IQR)) | 32 (16–51) | 43 (35–53) | 34 (20–46) | 0.475 |
BSA of the recipients at transplant (m2; median (IQR)) | 0.84 (0.72–0.93) | 0.89 (0.71–1.14) | 0.80 (0.70–0.83) | 0.492 |
Pretransplant time of the recipient on dialysis (months; median (IQR)) | 24 (15–33) | 21 (11–34) | 41 (21–53) | 0.105 |
HLA mismatches (n; median (IQR)) | 3 (2–3) | 3 (2–4) | 2 (2–3) | 0.652 |
Cold ischemia time of the graft (h; median (IQR)) | 12 (10–16) | 14 (8–17) | 12 (11–15) | 0.930 |
Urinary tract infections (n; median (IQR)) | 1 (0–2) | 2.5 (2–4) | 2 (0.5–3) | 0.045 |
Follow-up of kidney grafts (months; median (IQR)) | 114 (86–144) | 135 (122–152) | 126 (72–135) | 0.420 |
Parameter | HR (95% CI) | p |
---|---|---|
Organ donation | ||
Living donation | 1 (Reference) | |
Postmortem donation | 1.103 (0.132–9.235) | 0.928 |
Recipient sex | ||
Female | 1 (Reference) | |
Male | 2.587 (0.551–12.160) | 0.229 |
Age of the recipient (years; median (IQR)) | 0.928 (0.738–1.167) | 0.524 |
Age of the donor (years; median (IQR)) | 1.063 (1.011–1.119) | 0.018 |
BSA of the recipients at transplant (m2; median (IQR)) | 0.775 (0.021–28.18) | 0.889 |
Pretransplant time of the recipient on dialysis (months; median (IQR)) | 1.011 (0.989–1.042) | 0.489 |
HLA mismatches (n; median (IQR)) | 1.004 (0.503–1.901) | 0.990 |
Cold ischemia time of the graft (h; median (IQR)) | 1.013 (0.909–1.130) | 0.813 |
Urinary tract infections (n; median (IQR)) | 1.220 (1.024–1.454) | 0.026 |
Grouping | ||
Control (no LUTD) | 1 (Reference) | |
LUTD CIC group | 4.091 (0.789–21.200) | 0.093 |
LUTD no CIC | 3.197 (0.558–18.320) | 0.192 |
Parameter | HR (95% CI) | p |
---|---|---|
Age of the donor (years; median (IQR)) | 1.066 (0.999–1.136) | 0.051 |
Urinary tract infections (n; median (IQR)) | 1.192 (0.978–1.454) | 0.083 |
Grouping | ||
Control (no LUTD) | 1 (Reference) | |
LUTD CIC group | 0.978 (0.125–7.659) | 0.983 |
LUTD no CIC | 2.222 (0.357–13.834) | 0.392 |
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Marcou, M.; Galiano, M.; Tzschoppe, A.; Sauerstein, K.; Wach, S.; Taubert, H.; Wullich, B.; Hirsch-Koch, K.; Apel, H. Clean Intermittent Catheterization in Children under 12 Years Does Not Have a Negative Impact on Long-Term Graft Survival following Pediatric Kidney Transplantation. J. Clin. Med. 2024, 13, 33. https://doi.org/10.3390/jcm13010033
Marcou M, Galiano M, Tzschoppe A, Sauerstein K, Wach S, Taubert H, Wullich B, Hirsch-Koch K, Apel H. Clean Intermittent Catheterization in Children under 12 Years Does Not Have a Negative Impact on Long-Term Graft Survival following Pediatric Kidney Transplantation. Journal of Clinical Medicine. 2024; 13(1):33. https://doi.org/10.3390/jcm13010033
Chicago/Turabian StyleMarcou, Marios, Matthias Galiano, Anja Tzschoppe, Katja Sauerstein, Sven Wach, Helge Taubert, Bernd Wullich, Karin Hirsch-Koch, and Hendrik Apel. 2024. "Clean Intermittent Catheterization in Children under 12 Years Does Not Have a Negative Impact on Long-Term Graft Survival following Pediatric Kidney Transplantation" Journal of Clinical Medicine 13, no. 1: 33. https://doi.org/10.3390/jcm13010033
APA StyleMarcou, M., Galiano, M., Tzschoppe, A., Sauerstein, K., Wach, S., Taubert, H., Wullich, B., Hirsch-Koch, K., & Apel, H. (2024). Clean Intermittent Catheterization in Children under 12 Years Does Not Have a Negative Impact on Long-Term Graft Survival following Pediatric Kidney Transplantation. Journal of Clinical Medicine, 13(1), 33. https://doi.org/10.3390/jcm13010033