Therapeutic Anticoagulation Impacts MR Morphologic Recurrence Patterns in Glioblastoma—A Matched-Pair Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients and Data Collection
2.2. Image Analysis
2.3. Patient Follow-Up
2.4. Statistics
3. Results
4. Discussion
4.1. Multifocal and Midline-Crossing Relapse
4.2. Sharp Demarcated Lesions
4.3. Analysis of Intratumoral Hemorrhage
4.4. Progression-Free and Overall Survival
4.5. Limitations
4.6. Summary
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variable | Therapeutic Anticoagulation | Univariate | Multivariate | |
---|---|---|---|---|
Yes (n = 19) | No (n = 38) | p-Value | ||
Characteristics | ||||
Male, n (%) | 9 (47%) | 26 (68) | n.s. | n.s. |
Age, n (SD) | 62 (6) | 64 (8) | n.s. | n.s. |
Clinical course | ||||
Gross total resection, n (%) | 14 (73) | 25 (72) | n.s. | n.s. |
Subtotal resection, n (%) | 5 (27) | 13 (28) | n.s. | n.s. |
Progression-free survival, months (SD) | 13 (14) | 9.5 (7) | n.s. | n.s. |
Overall survival, months (SD) | 15 (15) | 12.5 (13) | n.s. | n.s. |
Histopathology | ||||
MGMT methylated | 10 (53) | 15 (40) | n.s. | n.s. |
MRI charateristics of reccurent tumor | ||||
Local | 10 (53) | 32 (84) | 0.02 | n.s. |
Multifocal | 9 (47) | 6 (16) | 0.02 | n.s. |
Midline crossing | 9 (47) | 4 (11) | 0.004 | 0.006 |
No midline crossing | 10 (53) | 34 (89) | 0.004 | 0.006 |
Hemorrhage | 0 (0) | 1 (3) | n.s. | n.s. |
No hemorrhage | 19 (100) | 37 (97) | n.s. | n.s. |
Sharp demarcation | 7 (37) | 4 (11) | 0.03 | 0.008 |
Without sharp demarcation | 12 (63) | 34 (89) | 0.03 | 0.008 |
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Dubinski, D.; Won, S.-Y.; Behmanesh, B.; Dosch, M.; Puchinin, V.; Baumgarten, P.; Bernstock, J.D.; Voss, M.; Schuss, P.; Konczalla, J.; et al. Therapeutic Anticoagulation Impacts MR Morphologic Recurrence Patterns in Glioblastoma—A Matched-Pair Analysis. J. Clin. Med. 2022, 11, 422. https://doi.org/10.3390/jcm11020422
Dubinski D, Won S-Y, Behmanesh B, Dosch M, Puchinin V, Baumgarten P, Bernstock JD, Voss M, Schuss P, Konczalla J, et al. Therapeutic Anticoagulation Impacts MR Morphologic Recurrence Patterns in Glioblastoma—A Matched-Pair Analysis. Journal of Clinical Medicine. 2022; 11(2):422. https://doi.org/10.3390/jcm11020422
Chicago/Turabian StyleDubinski, Daniel, Sae-Yeon Won, Bedjan Behmanesh, Max Dosch, Viktoria Puchinin, Peter Baumgarten, Joshua D. Bernstock, Martin Voss, Patrick Schuss, Jürgen Konczalla, and et al. 2022. "Therapeutic Anticoagulation Impacts MR Morphologic Recurrence Patterns in Glioblastoma—A Matched-Pair Analysis" Journal of Clinical Medicine 11, no. 2: 422. https://doi.org/10.3390/jcm11020422
APA StyleDubinski, D., Won, S.-Y., Behmanesh, B., Dosch, M., Puchinin, V., Baumgarten, P., Bernstock, J. D., Voss, M., Schuss, P., Konczalla, J., Czabanka, M., Freiman, T. M., & Gessler, F. (2022). Therapeutic Anticoagulation Impacts MR Morphologic Recurrence Patterns in Glioblastoma—A Matched-Pair Analysis. Journal of Clinical Medicine, 11(2), 422. https://doi.org/10.3390/jcm11020422