Effects of Obesity, Blood Pressure, and Blood Metabolic Biomarkers on Grey Matter Brain Healthcare Quotient: A Large Cohort Study of a Magnetic Resonance Imaging Brain Screening System in Japan
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Data Collection
2.3. MRI
2.4. Image Processing for Brain Volume
2.5. Statistical Analyses
2.6. Data Availability
3. Results
3.1. Data of Participants
3.2. Partial Correlation Analysis
3.3. Multiple Regression Analysis
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Number of participants (female) | 1799 (770) |
Age, mean ± SD | 62.0 ± 13.1 |
Self-reported neurologic symptom | |
Dizziness | 134 (69) |
Headache | 390 (223) |
Tinnitus | 330 (142) |
Subjective cognitive decline | 930 (455) |
None of the above | 588 (193) |
No answer | 27 (11) |
Small infarction | 218 (82) |
Microhaemorrhage | 236 (92) |
Both small infarction and microhaemorrhage | 67 (25) |
Mini-Mental State Examination, mean ± SD | 28.5 ± 2.2 |
Mean ± Standard Deviation (Range) | Partial Correlation | p | |
---|---|---|---|
Blood pressure | |||
systolic blood pressure | 126.6 ± 16.8 (87–206) mmHg | −0.10 | 0.001 * |
diastolic blood pressure | 73.4 ± 10.9 (45–128) mmHg | −0.06 | 0.03 |
heart rate | 63.1 ± 10.5 (37–117) bpm | −0.09 | 0.004 |
Obesity measurements | |||
body mass index | 22.9 ± 3.2 (14.2–48.4) | −0.19 | <0.001 * |
waist circumference | 82.6 ± 9.2 (55.5–127.6) cm | −0.07 | 0.009 |
body fat percentage | 24.5 ± 6.4 (7.0–48.5) % | −0.13 | <0.001 * |
Liver function | |||
total protein | 7.4 ± 0.4 (6.2–10.1) g/dL | 0.00 | 0.921 |
albumin | 4.4 ± 0.2 (3.4–5.5) g/dL | 0.01 | 0.758 |
total bilirubin | 0.8 ± 0.3 (0.2–3.5) mg/dL | 0.01 | 0.672 |
aspartate aminotransferase (AST) | 24.7 ± 11.5 (9–251) U/L | −0.11 | <0.001 * |
alanine aminotransferase (ALT) | 23.2 ± 15.5 (3–215) U/L | −0.12 | <0.001 * |
γ-glutamyltransferase (γ-GTP) | 41.0 ± 56.2 (7–1173) U/L | −0.13 | <0.001 * |
Renal function | |||
blood urea nitrogen (BUN) | 15.1 ± 4.0 (5.6–55.1) mg/dL | 0.00 | 0.984 |
creatinine (Cr) | 0.8 ± 0.3 (0.4–8.7) mg/dL | −0.01 | 0.559 |
uric acid | 5.3 ± 1.3 (0.7–11.1) mg/dL | −0.07 | 0.003 |
Lipid metabolism | |||
total cholesterol | 211.0 ± 54.3 (24–2013) mg/dL | 0.07 | 0.05 |
triglyceride cholesterol | 109.9 ± 69.8 (28–924) mg/dL | −0.12 | 0.744 |
high-density lipoprotein (HDL) | 64.4 ± 16.4 (30–155) mg/dL | −0.02 | 0.587 |
low-density lipoprotein (LDL) | 120.0 ± 30.3 (15–236) mg/dL | 0.05 | 0.147 |
Electrolytes | |||
Na | 141.0 ± 1.8 (131–146) mEq/L | 0.02 | 0.644 |
K | 4.1 ± 0.3 (2.6–5.3) mEq/L | −0.03 | 0.45 |
Cl | 102.7 ± 2.4 (95–111) mEq/L | 0.00 | 0.979 |
Ca | 9.4 ± 0.3 (7.6–11.0) mEq/L | 0.00 | 0.903 |
Glycometabolism | |||
fasting blood glucose (Glu) | 102.2 ± 19.3 (72–334) mg/dL | −0.12 | <0.001 * |
haemoglobin A1c (HbA1c) | 5.6 ± 0.6 (3.7–10.9) % | −0.09 | <0.001 * |
Blood cell values | |||
white blood cell count (WBC) | 54.8 ± 14.6 (18.4–169.3) × 102/μL | 0.01 | 0.792 |
red blood cell count (RBC) | 460.5 ± 43.9 (241–600) × 104/μL | −0.01 | 0.688 |
haemoglobin (Hb) | 14.4 ± 1.4 (7.7–19.0) g/dL | −0.05 | 0.061 |
haematocrit (Ht) | 42.3 ± 3.8 (24–55) % | −0.08 | 0.005 |
platelet count (PLT) | 22.6 ± 6.1 (5–169) × 104/μL | 0.01 | 0.657 |
fibrinogen | 288.0 ± 63.7 (140–630) mg/dL | 0.06 | 0.056 |
b | Standard Error | Standardization Coefficient | t-Value | p | |
---|---|---|---|---|---|
Systolic blood pressure | −0.01 | 0.01 | −0.25 | −0.13 | 0.194 |
Body mass index | −0.28 | 0.06 | −0.93 | −4.69 | <0.001 |
γ-glutamyltransferase (γ-GTP) | −0.01 | 0 | −0.45 | −2.41 | 0.016 |
Uric acid | −0.13 | 0.15 | −0.18 | −0.02 | 0.397 |
Fasting blood glucose | −0.02 | 0.01 | −0.37 | −1.97 | 0.049 |
Haematocrit | −0.01 | 0.05 | −0.18 | −0.847 | 0.901 |
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Watanabe, K.; Kakeda, S.; Nemoto, K.; Onoda, K.; Yamaguchi, S.; Kobayashi, S.; Yamakawa, Y. Effects of Obesity, Blood Pressure, and Blood Metabolic Biomarkers on Grey Matter Brain Healthcare Quotient: A Large Cohort Study of a Magnetic Resonance Imaging Brain Screening System in Japan. J. Clin. Med. 2022, 11, 2973. https://doi.org/10.3390/jcm11112973
Watanabe K, Kakeda S, Nemoto K, Onoda K, Yamaguchi S, Kobayashi S, Yamakawa Y. Effects of Obesity, Blood Pressure, and Blood Metabolic Biomarkers on Grey Matter Brain Healthcare Quotient: A Large Cohort Study of a Magnetic Resonance Imaging Brain Screening System in Japan. Journal of Clinical Medicine. 2022; 11(11):2973. https://doi.org/10.3390/jcm11112973
Chicago/Turabian StyleWatanabe, Keita, Shingo Kakeda, Kiyotaka Nemoto, Keiichi Onoda, Shuhei Yamaguchi, Shotai Kobayashi, and Yoshinori Yamakawa. 2022. "Effects of Obesity, Blood Pressure, and Blood Metabolic Biomarkers on Grey Matter Brain Healthcare Quotient: A Large Cohort Study of a Magnetic Resonance Imaging Brain Screening System in Japan" Journal of Clinical Medicine 11, no. 11: 2973. https://doi.org/10.3390/jcm11112973