Next Article in Journal
Use of Anti-Cytokine Therapy in Kidney Transplant Recipients with COVID-19
Previous Article in Journal
Can Coagulation System Disorders and Cytokine and Inflammatory Marker Levels Predict the Temporary Clinical Deterioration or Improvement of Septic Patients on ICU Admission?
Article

A Prospective Study on the Efficacy of Two Different Phlebotonic Therapies as a Bridge to Surgery in Patients with Advanced Hemorrhoidal Disease

1
Proctology Unit, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Largo A. Gemelli, 8, 00168 Rome, Italy
2
Department of Medicine and Translational Surgery, Università Cattolica del Sacro Cuore, Largo A. Gemelli, 8, 00168 Rome, Italy
*
Author to whom correspondence should be addressed.
Raffaele Orefice, Francesco Litta and Angelo Parello contributed equally to this article.
J. Clin. Med. 2021, 10(8), 1549; https://doi.org/10.3390/jcm10081549
Received: 9 February 2021 / Revised: 22 March 2021 / Accepted: 31 March 2021 / Published: 7 April 2021
(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
The aims of this study were to evaluate the efficacy of two different phlebotonic therapies, preoperatively administered in advanced hemorrhoidal disease (HD) patients with recommendation for surgery, and to assess patient satisfaction after treatment. In this prospective observational study, 100 patients were preoperatively treated either with micronized purified flavonoid fraction (group A) or sublingual nano-emulsion flavonoid (group B). HD symptoms, local inflammation signs and patients’ satisfaction were evaluated at baseline visit (T0), after 4 weeks of therapy (T1) and 8 weeks after its discontinuation (T2). In group A, a significant improvement for all HD symptoms and inflammation signs was observed after therapy (T1), followed by a reduction of efficacy in T2, except for itching and edema. In group B, therapy had a significant benefit on symptoms and local inflammation at T1, which persisted after its discontinuation for all symptoms, and edematous hemorrhoids. In both groups, the satisfaction rate was “good” in 60% of patients and patients were statistically significant more satisfied at T1 compared with T2 (p = 0.0001). No adverse events were recorded. Preoperative treatment was safe and useful to optimize patients’ clinical condition prior to surgery. View Full-Text
Keywords: phlebotonic therapies; hemorrhoidal disease; surgical treatment; quality of life phlebotonic therapies; hemorrhoidal disease; surgical treatment; quality of life
Show Figures

Figure 1

MDPI and ACS Style

Orefice, R.; Litta, F.; Parello, A.; De Simone, V.; Campennì, P.; Marra, A.A.; Ratto, C. A Prospective Study on the Efficacy of Two Different Phlebotonic Therapies as a Bridge to Surgery in Patients with Advanced Hemorrhoidal Disease. J. Clin. Med. 2021, 10, 1549. https://doi.org/10.3390/jcm10081549

AMA Style

Orefice R, Litta F, Parello A, De Simone V, Campennì P, Marra AA, Ratto C. A Prospective Study on the Efficacy of Two Different Phlebotonic Therapies as a Bridge to Surgery in Patients with Advanced Hemorrhoidal Disease. Journal of Clinical Medicine. 2021; 10(8):1549. https://doi.org/10.3390/jcm10081549

Chicago/Turabian Style

Orefice, Raffaele, Francesco Litta, Angelo Parello, Veronica De Simone, Paola Campennì, Angelo A. Marra, and Carlo Ratto. 2021. "A Prospective Study on the Efficacy of Two Different Phlebotonic Therapies as a Bridge to Surgery in Patients with Advanced Hemorrhoidal Disease" Journal of Clinical Medicine 10, no. 8: 1549. https://doi.org/10.3390/jcm10081549

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop