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Article

Anti-SARS-CoV-2 S-RBD IgG Antibody Responses after COVID-19 mRNA Vaccine in the Chronic Disorder of Consciousness: A Pilot Study

1
Intensive Rehabilitation Unit, S’Anna Institute, 88900 Crotone, Italy
2
Institute for Biomedical Research and Innovation (IRIB), National Research Council of Italy, 98164 Messina, Italy
3
Pharmacotechnology Documentation and Transfer Unit, Preclinical and Translational Pharmacology, Department of Pharmacy, Health Science and Nutrition, University of Calabria, 87036 Rende, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Nicola Petrosillo and Jose-Manuel Ramos-Rincon
J. Clin. Med. 2021, 10(24), 5830; https://doi.org/10.3390/jcm10245830
Received: 8 October 2021 / Revised: 24 November 2021 / Accepted: 9 December 2021 / Published: 13 December 2021
(This article belongs to the Special Issue COVID-19: Special Populations and Risk Factors)
Objective: In the last year, a large amount of research has investigated the anti-spike protein receptor-binding domain (S-RBD) antibody responses in patients at high risk of developing severe acute respiratory syndrome because of COVID-19 infection. However, no data are available on the chronic disorder of consciousness (DOC). Methods: Here, we evaluated anti-S-RBD IgG levels after vaccination in chronic DOC patients compared with demographically matched healthy controls (HC) by indirect chemiluminescence immunoassay. All individuals completed a two-dose-cycle vaccination with Pfizer mRNA vaccine (BNT162b2), and antibody responses were evaluated at 30 and 180 days after the administration of the second dose of vaccination. Results: We compared 32 DOC patients with 34 demographically matched healthy controls. Both DOC and HC groups showed a similar antibody response at 30 days, whereas at follow-up (180 days) DOC patients were characterized by lower S-RBD IgG levels with respect to controls. Additional multiple regression analyses including demographical and clinical comorbidities as predictors revealed that age was the only factor associated with the decrease in S-RBD IgG levels at follow-up (180 days). Elderly individuals of both groups were characterized by a reduction in the antibody responses with respect to younger individuals. Conclusions: Our results show an efficacy seroconversion in DOC patients in the first period after vaccination, which significantly declines over time with respect to healthy controls. View Full-Text
Keywords: COVID-19; disorder of consciousness; vaccination; antibody responses COVID-19; disorder of consciousness; vaccination; antibody responses
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MDPI and ACS Style

Pugliese, M.E.; Battaglia, R.; Cerasa, A.; Raso, M.G.; Coschignano, F.; Pagliuso, A.; Bruschetta, R.; Pugliese, G.; Scola, P.; Tonin, P. Anti-SARS-CoV-2 S-RBD IgG Antibody Responses after COVID-19 mRNA Vaccine in the Chronic Disorder of Consciousness: A Pilot Study. J. Clin. Med. 2021, 10, 5830. https://doi.org/10.3390/jcm10245830

AMA Style

Pugliese ME, Battaglia R, Cerasa A, Raso MG, Coschignano F, Pagliuso A, Bruschetta R, Pugliese G, Scola P, Tonin P. Anti-SARS-CoV-2 S-RBD IgG Antibody Responses after COVID-19 mRNA Vaccine in the Chronic Disorder of Consciousness: A Pilot Study. Journal of Clinical Medicine. 2021; 10(24):5830. https://doi.org/10.3390/jcm10245830

Chicago/Turabian Style

Pugliese, Maria E., Riccardo Battaglia, Antonio Cerasa, Maria G. Raso, Francesco Coschignano, Angela Pagliuso, Roberta Bruschetta, Giovanni Pugliese, Paolo Scola, and Paolo Tonin. 2021. "Anti-SARS-CoV-2 S-RBD IgG Antibody Responses after COVID-19 mRNA Vaccine in the Chronic Disorder of Consciousness: A Pilot Study" Journal of Clinical Medicine 10, no. 24: 5830. https://doi.org/10.3390/jcm10245830

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