Next Article in Journal
Craniofacial Osteomas: From Diagnosis to Therapy
Next Article in Special Issue
Alteration of Serum Proteome in Levo-Thyroxine-Euthyroid Thyroidectomized Patients
Previous Article in Journal
Similar Adaptations to 10 Weeks Concurrent Training on Metabolic Markers and Physical Performance in Young, Adult, and Older Adult Women
Previous Article in Special Issue
An Underestimated Toxicity Radiation-Induced Hypothyroidism in Patients Multimodally Treated for Breast Cancer
Article

Diagnostic Re-Evaluation and Potential Predictor Factors of Transient and Permanent Congenital Hypothyroidism in Eutopic Thyroid Gland

1
Department of Pediatric Endocrinology, Regina Margherita Children’s Hospital, City of Health and Science University Hospital of Turin, 10126 Turin, Italy
2
Department of Public Health and Pediatric Sciences, University of Turin, 10124 Turin, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Malgorzata Gabriela Wasniewska and Aviram Mizrachi
J. Clin. Med. 2021, 10(23), 5583; https://doi.org/10.3390/jcm10235583
Received: 3 November 2021 / Revised: 19 November 2021 / Accepted: 26 November 2021 / Published: 27 November 2021
(This article belongs to the Special Issue Hypothyroidism: Causes, Effects and Current Treatments)
Background: The incidence of congenital hypothyroidism (CH) has increased over the years, and many predictors for detecting newborns with transient forms (TCH) as early as possible have been considered. Methods: All newborns diagnosed with primary CH and eutopic gland in the Piedmont region of Italy in the period of January 2014–June 2019 were enrolled and re-evaluated at the age of 2 years. Results: 105 newborns were diagnosed with CH during the study period. Dyshormonogenesis was observed in 55/105. At re-evaluation, we found that 52.7% had permanent CH (PCH), while 47.3% had TCH. Male/female rate, TSH levels at diagnosis, levothyroxine requirement at withdrawal and extra-thyroid congenital malformations rate were higher in the PCH group (p = 0.02, p = 0.009, p = 0.02 and p = 0.01), while fT4 levels at diagnosis were lower (p = 0.03). Sensitivity of 72.4% and specificity of 80.7% for serum TSH above 60 mcUI/mL, sensitivity of 73% and specificity of 72.4% for serum fT4 level below 7.2 pg/mL and sensitivity of 66% and specificity of 68% for drug requirement above 2.25 mcg/kg/day were observed in PCH. Conclusions: Demographic, clinical and hormonal data at diagnosis and levothyroxine requirement during the first two years should be adequately monitored to identify infants who are most likely to discontinue therapy after the age of 24 months. View Full-Text
Keywords: transient congenital hypothyroidism; permanent congenital hypothyroidism; eutopic thyroid gland; predictive factors transient congenital hypothyroidism; permanent congenital hypothyroidism; eutopic thyroid gland; predictive factors
Show Figures

Figure 1

MDPI and ACS Style

Tuli, G.; Munarin, J.; De Sanctis, L. Diagnostic Re-Evaluation and Potential Predictor Factors of Transient and Permanent Congenital Hypothyroidism in Eutopic Thyroid Gland. J. Clin. Med. 2021, 10, 5583. https://doi.org/10.3390/jcm10235583

AMA Style

Tuli G, Munarin J, De Sanctis L. Diagnostic Re-Evaluation and Potential Predictor Factors of Transient and Permanent Congenital Hypothyroidism in Eutopic Thyroid Gland. Journal of Clinical Medicine. 2021; 10(23):5583. https://doi.org/10.3390/jcm10235583

Chicago/Turabian Style

Tuli, Gerdi, Jessica Munarin, and Luisa De Sanctis. 2021. "Diagnostic Re-Evaluation and Potential Predictor Factors of Transient and Permanent Congenital Hypothyroidism in Eutopic Thyroid Gland" Journal of Clinical Medicine 10, no. 23: 5583. https://doi.org/10.3390/jcm10235583

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop