Diagnostic Re-Evaluation and Potential Predictor Factors of Transient and Permanent Congenital Hypothyroidism in Eutopic Thyroid Gland

Tuli, Gerdi; Munarin, Jessica; De Sanctis, Luisa

doi:10.3390/jcm10235583

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Diagnostic Re-Evaluation and Potential Predictor Factors of Transient and Permanent Congenital Hypothyroidism in Eutopic Thyroid Gland

Gerdi Tuli

^1,2,*,

Jessica Munarin

^1,2 and

Luisa De Sanctis

^1,2

Department of Pediatric Endocrinology, Regina Margherita Children’s Hospital, City of Health and Science University Hospital of Turin, 10126 Turin, Italy

Department of Public Health and Pediatric Sciences, University of Turin, 10124 Turin, Italy

Author to whom correspondence should be addressed.

Academic Editors: Malgorzata Gabriela Wasniewska and Aviram Mizrachi

J. Clin. Med. 2021, 10(23), 5583; https://doi.org/10.3390/jcm10235583

Received: 3 November 2021 / Revised: 19 November 2021 / Accepted: 26 November 2021 / Published: 27 November 2021

(This article belongs to the Special Issue Hypothyroidism: Causes, Effects and Current Treatments)

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Abstract

Background: The incidence of congenital hypothyroidism (CH) has increased over the years, and many predictors for detecting newborns with transient forms (TCH) as early as possible have been considered. Methods: All newborns diagnosed with primary CH and eutopic gland in the Piedmont region of Italy in the period of January 2014–June 2019 were enrolled and re-evaluated at the age of 2 years. Results: 105 newborns were diagnosed with CH during the study period. Dyshormonogenesis was observed in 55/105. At re-evaluation, we found that 52.7% had permanent CH (PCH), while 47.3% had TCH. Male/female rate, TSH levels at diagnosis, levothyroxine requirement at withdrawal and extra-thyroid congenital malformations rate were higher in the PCH group (p = 0.02, p = 0.009, p = 0.02 and p = 0.01), while fT4 levels at diagnosis were lower (p = 0.03). Sensitivity of 72.4% and specificity of 80.7% for serum TSH above 60 mcUI/mL, sensitivity of 73% and specificity of 72.4% for serum fT4 level below 7.2 pg/mL and sensitivity of 66% and specificity of 68% for drug requirement above 2.25 mcg/kg/day were observed in PCH. Conclusions: Demographic, clinical and hormonal data at diagnosis and levothyroxine requirement during the first two years should be adequately monitored to identify infants who are most likely to discontinue therapy after the age of 24 months. View Full-Text

Keywords: transient congenital hypothyroidism; permanent congenital hypothyroidism; eutopic thyroid gland; predictive factors

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Tuli, G.; Munarin, J.; De Sanctis, L. Diagnostic Re-Evaluation and Potential Predictor Factors of Transient and Permanent Congenital Hypothyroidism in Eutopic Thyroid Gland. J. Clin. Med. 2021, 10, 5583. https://doi.org/10.3390/jcm10235583

AMA Style

Tuli G, Munarin J, De Sanctis L. Diagnostic Re-Evaluation and Potential Predictor Factors of Transient and Permanent Congenital Hypothyroidism in Eutopic Thyroid Gland. Journal of Clinical Medicine. 2021; 10(23):5583. https://doi.org/10.3390/jcm10235583

Chicago/Turabian Style

Tuli, Gerdi, Jessica Munarin, and Luisa De Sanctis. 2021. "Diagnostic Re-Evaluation and Potential Predictor Factors of Transient and Permanent Congenital Hypothyroidism in Eutopic Thyroid Gland" Journal of Clinical Medicine 10, no. 23: 5583. https://doi.org/10.3390/jcm10235583

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Diagnostic Re-Evaluation and Potential Predictor Factors of Transient and Permanent Congenital Hypothyroidism in Eutopic Thyroid Gland

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