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Article

Evaluation of Two Rapid Antigenic Tests for the Detection of SARS-CoV-2 in Nasopharyngeal Swabs

1
Department of Clinical Microbiology, Center for Interdisciplinary Research on Medicines (CIRM), University of Liège, 4000 Liège, Belgium
2
Biostatistics Unit, Department of Public Health, University of Liège, 4000 Liège, Belgium
*
Author to whom correspondence should be addressed.
Academic Editor: Robert Flisiak
J. Clin. Med. 2021, 10(13), 2774; https://doi.org/10.3390/jcm10132774
Received: 7 June 2021 / Accepted: 16 June 2021 / Published: 24 June 2021
(This article belongs to the Special Issue Updates in Management of SARS-CoV-2 Infection)
(1) Background: In the current context of the COVID-19 crisis, there is a need for fast, easy-to-use, and sensitive diagnostic tools in addition to molecular methods. We have therefore decided to evaluate the performance of newly available antigen detection kits in “real-life” laboratory conditions. (2) Methods: The sensitivity and specificity of two rapid diagnostic tests (RDT)—the COVID-19 Ag Respi-Strip from Coris Bioconcept, Belgium (CoRDT), and the coronavirus antigen rapid test cassette from Healgen Scientific, LLC, USA (HeRDT)—were evaluated on 193 nasopharyngeal samples using RT-PCR as the gold standard. (3) Results: The sensitivity obtained for HeRDT was 88% for all collected samples and 91.1% for samples with Ct ≤ 31. For the CoRDT test, the sensitivity obtained was 62% for all collected samples and 68.9% for samples with Ct ≤ 31. (4) Conclusions: Despite the excellent specificity obtained for both kits, the poor sensitivity of the CoRDT did not allow for its use in the rapid diagnosis of COVID-19. HeRDT satisfied the World Health Organization’s performance criteria for rapid antigen detection tests. Its high sensitivity, quick response, and ease of use allowed for the implementation of HeRDT at the laboratory of the University Hospital of Liège. View Full-Text
Keywords: rapid diagnostic test; antigen detection; SARS-CoV-2; COVID-19 rapid diagnostic test; antigen detection; SARS-CoV-2; COVID-19
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MDPI and ACS Style

Seynaeve, Y.; Heylen, J.; Fontaine, C.; Maclot, F.; Meex, C.; Diep, A.N.; Donneau, A.-F.; Hayette, M.-P.; Descy, J. Evaluation of Two Rapid Antigenic Tests for the Detection of SARS-CoV-2 in Nasopharyngeal Swabs. J. Clin. Med. 2021, 10, 2774. https://doi.org/10.3390/jcm10132774

AMA Style

Seynaeve Y, Heylen J, Fontaine C, Maclot F, Meex C, Diep AN, Donneau A-F, Hayette M-P, Descy J. Evaluation of Two Rapid Antigenic Tests for the Detection of SARS-CoV-2 in Nasopharyngeal Swabs. Journal of Clinical Medicine. 2021; 10(13):2774. https://doi.org/10.3390/jcm10132774

Chicago/Turabian Style

Seynaeve, Ysaline, Justine Heylen, Corentin Fontaine, François Maclot, Cécile Meex, Anh N. Diep, Anne-Françoise Donneau, Marie-Pierre Hayette, and Julie Descy. 2021. "Evaluation of Two Rapid Antigenic Tests for the Detection of SARS-CoV-2 in Nasopharyngeal Swabs" Journal of Clinical Medicine 10, no. 13: 2774. https://doi.org/10.3390/jcm10132774

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