Glaucoma Progression after Delivery in Patients with Open-Angle Glaucoma Who Discontinued Glaucoma Medication during Pregnancy
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Determination of Glaucoma Progression
2.3. Statistical Analyses
3. Results
Participant Characteristics
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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All Subjects (N = 37) | |
---|---|
Age (yr) | 32.40 ± 2.94 |
Number of eyes | 67 |
Right eyes | 34 (50.7%) |
Left eyes | 33 (49.3%) |
Prior pregnancies | 0.09 ± 0.29 |
Number of medications in pre-pregnancy | 1.55 ± 0.91 |
Pre-pregnancy IOP (mmHg) | 14.21 ± 2.54 |
Pre-pregnancy MD (dB) | −5.25 ± 5.11 |
Pre-pregnancy PSD (dB) | 5.62 ± 4.43 |
Pre-pregnancy RNFL thickness (µm) | 75.55 ± 10.18 |
Follow-up periods after pregnancy (months) | 45.67 ± 24.07 |
Diagnosis | |
Normal-tension glaucoma | 44 (65.7%) |
Primary open-angle glaucoma | 23 (34.3%) |
Progression (N = 19) | Non-Progression (N = 48) | p Value | |
---|---|---|---|
Age | 32.21 ± 2.04 | 32.48 ± 3.25 | 0.97 |
Number of pre-pregnancy medications | 0.16 ± 0.38 | 0.06 ± 0.25 | 0.22 |
Pre-pregnancy IOP (mmHg) | 14.79 ± 2.89 | 13.99 ± 2.38 | 0.25 |
First trimester IOP (mmHg) | 15.75 ± 3.31 | 13.86 ± 2.15 | 0.02 |
Second trimester IOP (mmHg) | 16.50 ± 2.80 | 13.62 ± 2.28 | 0.001 |
Third trimester IOP (mmHg) | 17.67 ± 1.56 | 14.44 ± 3.17 | 0.04 |
Postpartum IOP (mmHg) | 15.48 ± 2.29 | 14.16 ± 2.61 | 0.06 |
MD (dB) | −4.52 ± 4.83 | −5.56 ± 5.25 | 0.33 |
PSD (dB) | 5.15 ± 4.05 | 5.82 ± 4.60 | 0.63 |
RNFL thickness (µm) | |||
Average | 74.42 ± 9.73 | 76.02 ± 10.42 | 0.56 |
Temporal | 64.68 ± 13.77 | 65.43 ± 16.04 | 0.86 |
Superior | 94.53 ± 20.39 | 95.07 ± 22.28 | 0.93 |
Nasal | 58.16 ± 11.01 | 60.54 ± 9.15 | 0.41 |
Inferior | 81.00 ± 16.53 | 82.74 ± 22.52 | 0.78 |
Diagnosis | 0.08 | ||
Normal-tension glaucoma | 9 | 35 | |
Primary open-angle glaucoma | 10 | 13 |
Variable | Coefficient (95% CI) | p Value |
---|---|---|
Age | 0.991 (0.819–1.198) | 0.923 |
Prepreg. No | 0.349 (0.043–2.833) | 0.324 |
Diagnosis (NTG/HTG) | 0.405 (0.120–1.373) | 0.147 |
Number of medications before pregnancy | 0.280 (0.056–1.411) | 0.123 |
Progression before pregnancy | 0.565 (0.242–1.318) | 0.187 |
Pre-pregnancy IOP (mmHg) | 1.103 (0.907–1.341) | 0.328 |
First trimester IOP (mmHg) | 1.229 (0.969–1.559) | 0.089 |
Second trimester IOP (mmHg) | 1.437 (1.017–2.031) | 0.040 |
Third trimester IOP (mmHg) | 1.755 (1.054–2.924) | 0.031 |
IOP fluctuation in pregnancy (mmHg) | 1.373 (1.039–1.814) | 0.026 |
Postpartum IOP (mmHg) | 1.088 (0.897–1.319) | 0.393 |
MD (dB) | 1.007 (0.942–1.076) | 0.835 |
PSD (dB) | 1.015 (0.923–1.115) | 0.764 |
RNFL thickness | ||
Average | 0.992 (0.977–1.008) | 0.344 |
Temporal | 1.003 (0.987–1.019) | 0.721 |
Superior | 0.995 (0.981–1.009) | 0.496 |
Nasal | 1.008 (0.964–1.054) | 0.721 |
Inferior | 0.994 (0.977–1.012) | 0.521 |
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Seo, D.; Lee, T.; Kim, J.Y.; Seong, G.J.; Choi, W.; Bae, H.W.; Kim, C.Y. Glaucoma Progression after Delivery in Patients with Open-Angle Glaucoma Who Discontinued Glaucoma Medication during Pregnancy. J. Clin. Med. 2021, 10, 2190. https://doi.org/10.3390/jcm10102190
Seo D, Lee T, Kim JY, Seong GJ, Choi W, Bae HW, Kim CY. Glaucoma Progression after Delivery in Patients with Open-Angle Glaucoma Who Discontinued Glaucoma Medication during Pregnancy. Journal of Clinical Medicine. 2021; 10(10):2190. https://doi.org/10.3390/jcm10102190
Chicago/Turabian StyleSeo, Duri, Taekjune Lee, Joo Yeon Kim, Gong Je Seong, Wungrak Choi, Hyong Won Bae, and Chan Yun Kim. 2021. "Glaucoma Progression after Delivery in Patients with Open-Angle Glaucoma Who Discontinued Glaucoma Medication during Pregnancy" Journal of Clinical Medicine 10, no. 10: 2190. https://doi.org/10.3390/jcm10102190
APA StyleSeo, D., Lee, T., Kim, J. Y., Seong, G. J., Choi, W., Bae, H. W., & Kim, C. Y. (2021). Glaucoma Progression after Delivery in Patients with Open-Angle Glaucoma Who Discontinued Glaucoma Medication during Pregnancy. Journal of Clinical Medicine, 10(10), 2190. https://doi.org/10.3390/jcm10102190