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Open AccessArticle

Purification of Pharmaceutical Solvents by Pervaporation through Hybrid Silica Membranes

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Aix-Marseille Université, CNRS Centrale Marseille, M2P2 UMR 7340, Equipe Procédés Membranaires (EPM), Europôle de l’Arbois, BP80, Pavillon Laennec, Hall C, 13545 Aix-en-Provence, CEDEX, France
2
Céramiques Techniques Industrielles (CTI), 382 Avenue du Moulinas, 30340 Salindres, France
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Authors to whom correspondence should be addressed.
Membranes 2019, 9(7), 76; https://doi.org/10.3390/membranes9070076
Received: 11 April 2019 / Revised: 24 May 2019 / Accepted: 26 June 2019 / Published: 1 July 2019
(This article belongs to the Special Issue Point-of-use Membrane Technologies: Challenges and Opportunities)
Solvents purification mainly used in pharmaceutical field such as acetone and methyl ethyl ketone (MEK) were performed through hybrid silica membranes and from binary and multi-components mixtures. Two hybrid silica membranes—zirconia doped bis(triethoxysilyl)methane and bis(triethoxysilyl)ethane (BTESE)—were studied. Flux, permeance, and separation factor were evaluated depending on temperature, composition, and number of organic compounds in the feed. Dehydration tests of acetone were operated at 30 and 45 °C following by acetone and MEK purification at 50 °C from multi-components hydro-organic mixtures where hydrophilic compounds (water, methanol) but also hydrophobic (dichloromethane (DCM) and/or toluene) were present. Results showed that the presence of Zr nanoparticles affected flux and improved selectivity in the case of dehydration. Experiments related to acetone and MEK purification, revealed a mass transfer alteration and a decrease of performance, from 99 to 97 wt% and from 98 to 95 wt% respectively, when the number of compounds in the initial feed grown up and more precisely, in the presence of DCM and toluene thus highlighting a possible coupling effect. View Full-Text
Keywords: solvents purification; pervaporation; hybrid silica membrane; coupling effect solvents purification; pervaporation; hybrid silica membrane; coupling effect
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MDPI and ACS Style

La Rocca, T.; Carretier, E.; Dhaler, D.; Louradour, E.; Truong, T.; Moulin, P. Purification of Pharmaceutical Solvents by Pervaporation through Hybrid Silica Membranes. Membranes 2019, 9, 76.

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