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Continuous Membrane-Based Screening System for Biocatalysis

Chair of Chemical and Process Engineering, Technische Universität Berlin, Sekr. MA 5-7, Straße des 17. Juni 135, 10623 Berlin, Germany
HTW Berlin, Department of Engineering II, School of Life Science Engineering, Wilhelminenhofstr. 75a, 12459 Berlin, Germany
Institute for Chemistry, Department of Enzyme Technology, Technische Universität Berlin, Sekr. TC 4, Straße des 17. Juni 124, 10623 Berlin, Germany
Author to whom correspondence should be addressed.
Membranes 2011, 1(1), 70-79;
Received: 30 December 2010 / Revised: 17 February 2011 / Accepted: 17 February 2011 / Published: 25 February 2011
(This article belongs to the Special Issue Selected Papers from the AMS6/IMSTEC10 Conference)
PDF [317 KB, uploaded 25 February 2011]


The use of membrane reactors for enzymatic and co-factor regenerating reactions offers versatile advantages such as higher conversion rates and space-time-yields and is therefore often applied in industry. However, currently available screening and kinetics characterization systems are based on batch and fed-batch operated reactors and were developed for whole cell biotransformations rather than for enzymatic catalysis. Therefore, the data obtained from such systems has only limited transferability for continuous membrane reactors. The aim of this study is to evaluate and to improve a novel screening and characterization system based on the membrane reactor concept using the enzymatic hydrolysis of cellulose as a model reaction. Important aspects for the applicability of the developed system such as long-term stability and reproducibility of continuous experiments were very high. The concept used for flow control and fouling suppression allowed control of the residence time with a high degree of precision (±1% accuracy) in a long-term study (>100 h). View Full-Text
Keywords: screening system; enzyme membrane reactor; membrane continuous stirred tank reactor; cellulose hydrolysis; fouling control screening system; enzyme membrane reactor; membrane continuous stirred tank reactor; cellulose hydrolysis; fouling control
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Lyagin, E.; Drews, A.; Bhattacharya, S.; Kraume, M. Continuous Membrane-Based Screening System for Biocatalysis. Membranes 2011, 1, 70-79.

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