A Study of Hepatitis A Seroprevalence in a Paediatric and Adolescent Population of the Province of Florence (Italy) in the Period 2017–2018 Confirms Tuscany a Low Endemic Area
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Hepatitis A Antibodies Qualitative Measurement
3.2. Hepatitis A Notification, Vaccination Status, and Seroprevalence Assessment
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Age Groups (years) | Nationality (N) | Sex (N) | Enrolled Subjects (N) | ||
---|---|---|---|---|---|
Italian | Non-Italian | Male | Female | ||
1–4 | 27 | 13 | 19 | 21 | 40 |
5–9 | 41 | 7 | 27 | 21 | 48 |
10–14 | 43 | 7 | 27 | 23 | 50 |
15–18 | 26 | 1 | 14 | 13 | 27 |
TOTAL | 137 | 28 | 87 | 78 | 165 |
Anti-HAV Seroprevalence | ||
---|---|---|
Group | Positive % (n/N) | Negative % (n/N) |
Overall | 9.1 (15/165) | 90.9 (150/165) |
Male | 10.3 (9/87) | 89.7 (78/87) |
Female | 7.7 (6/78) | 92.3 (72/78) |
Italian | 7.3 (10/137) | 92.7 (127/137) |
Non-Italian | 17.9 (5/28) | 82.1 (23/28) |
Dependent Variable: Anti-HAV Positive | |||||
---|---|---|---|---|---|
OR | SE | CI 95% | p-Value | ||
Sex | Female | - | - | - | - |
Male | 0.678 | 0.563 | 0.225–2.046 | 0.491 | |
Nationality | Italian | - | - | - | - |
Non-Italian | 0.264 | 0.641 | 0.075–0.926 | 0.037 | |
Age | - | 0.920 | 0.060 | 0.817–1.035 | 0.165 |
Variable | Group | Vaccinated % (n/N) | Unvaccinated % (n/N) |
---|---|---|---|
Age Group (years) | 1–4 | 0.0 (0/40) | 100.0 (40/40) |
5–9 | 4.2 (2/48) | 95.8 (46/48) | |
10–14 | 8.0 (4/50) | 92.0 (46/50) | |
15–18 | 3.7 (1/27) | 96.3 (26/27) | |
Sex | Female | 5.1 (4/78) | 94.9 (74/78) |
Male | 3.4 (3/87) | 96.6 (84/87) | |
Nationality | Italian | 3.6 (5/137) | 96.4 (132/137) |
Non-Italian | 7.1 (2/28) | 92.9 (26/28) | |
Total | 4.2 (7/165) | 95.8 (158/165) |
Anti-HAV Seroprevalence | ||||
---|---|---|---|---|
Group | Age Group (Years) | Positive % (n/N) | Negative % (n/N) | Total % (n/N) |
Vaccinated | 1–4 | 0.0 (0/0) | 0.0 (0/0) | 0.0 (0/7) |
5–9 | 100.0 (2/2) | 0.0 (0/2) | 28.6 (2/7) | |
10–14 | 100.0 (4/4) | 0.0 (0/4) | 71.4 (5/7) | |
15–18 Total | 100.0 (1/1) 100.0 (7/7) | 0.0 (0/1) 0.0 (0/7) | 14.3 (1/7) 4.2 (7/165) | |
Unvaccinated | 1–4 | 2.5 (1/40) | 97.5 (39/40) | 25.3 (40/158) |
5–9 | 4.3 (2/46) | 95.7 (44/46) | 29.1 (46/158) | |
10–14 | 10.9 (5/46) | 89.1 (41/46) | 29.1 (46/158) | |
15–18 Total | 0.0 (0/26) 5.1 (8/158) | 100.0 (26/26) 94.9 (150/158) | 16.5 (26/158) 95.8 (158/165) |
Anti-HAV Antibodies | |||
---|---|---|---|
Anti-HAV Vaccination According to Anamnestic Memory of Vaccination | Anti-HAV Vaccination According to Regional Vaccination Registry | Negative % (n/N) | Positive % (n/N) |
No | No | 96.7 (145/150) | 3.3 (5/150) |
Yes | 0.0 (0/2) | 100.0 (2/2) | |
I don’t remember\I don’t know | No | 83.3 (5/6) | 6.7 (1/6) |
Yes | 0.0 (0/1) | 100.0 (1/1) | |
Yes | No | 0.0 (0/2) | 100.0 (2/2) |
Yes | 0.0 (0/4) | 100.0 (4/4) |
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Zanella, B.; Boccalini, S.; Biamonte, M.A.; Giorgetti, D.; Menicacci, M.; Bonito, B.; Ninci, A.; Tiscione, E.; Puggelli, F.; Mereu, G.; et al. A Study of Hepatitis A Seroprevalence in a Paediatric and Adolescent Population of the Province of Florence (Italy) in the Period 2017–2018 Confirms Tuscany a Low Endemic Area. Vaccines 2021, 9, 1194. https://doi.org/10.3390/vaccines9101194
Zanella B, Boccalini S, Biamonte MA, Giorgetti D, Menicacci M, Bonito B, Ninci A, Tiscione E, Puggelli F, Mereu G, et al. A Study of Hepatitis A Seroprevalence in a Paediatric and Adolescent Population of the Province of Florence (Italy) in the Period 2017–2018 Confirms Tuscany a Low Endemic Area. Vaccines. 2021; 9(10):1194. https://doi.org/10.3390/vaccines9101194
Chicago/Turabian StyleZanella, Beatrice, Sara Boccalini, Massimiliano Alberto Biamonte, Duccio Giorgetti, Marco Menicacci, Benedetta Bonito, Alessandra Ninci, Emilia Tiscione, Francesco Puggelli, Giovanna Mereu, and et al. 2021. "A Study of Hepatitis A Seroprevalence in a Paediatric and Adolescent Population of the Province of Florence (Italy) in the Period 2017–2018 Confirms Tuscany a Low Endemic Area" Vaccines 9, no. 10: 1194. https://doi.org/10.3390/vaccines9101194