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Impact of Pneumococcal Vaccination in the Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children of the Murcia Region in Spain

1
Pediatrics Infectious Disease and Virgen de la Arrixaca Hospital, 30120 Murcia, Spain
2
Microbiology Department, Virgen de la Arrixaca Hospital, 30120 Murcia, Spain
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Pneumoccocal Reference Laboratory CNM-ISCIII, 28220 Madrid, Spain
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Microbiology Department S, Lucía Hospital, 30202 Cartagena, Spain
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Barrio del Peral Health care Center, 30300 Cartagena, Spain
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Microbiology Department Morales Meseguer Hospital, 30008 Murcia, Spain
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El Ranero Health care Center, 30009 Murcia, Spain
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Parrado Moreno L Los Arcos-Mar Menor Hospital, 30739 San Javier, Spain
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San Javier Health care Center, 30730 San Javier, Spain
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Microbiology Department Rafael Méndez Hospital, 30739 San Javier, Spain
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Totana Health care Center, 30850 Murcia, Sapin
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Ronda Sur. Health care Center, 30010 Murcia, Spain
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Microbiology Department V del Castillo Hospital, 30510 Yecla, Spain
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Pediatrician. Centro de Salud Mariano Yago, 30510 Yecla, Spain
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Santa María de Gracia Health care Center, 30009 Murcia, Spain
*
Authors to whom correspondence should be addressed.
Membership of the Murcian Pneumococcal Study Group is provided in the Acknowledgments.
Vaccines 2021, 9(1), 14; https://doi.org/10.3390/vaccines9010014
Received: 28 November 2020 / Revised: 21 December 2020 / Accepted: 23 December 2020 / Published: 28 December 2020
(This article belongs to the Special Issue Recent Advances in Novel Pneumococcal Vaccines)
Background: An epidemiological study of Streptococcus pneumoniae nasopharyngeal carriage in healthy children was carried out five years after the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13). Objectives: Study the impact of pediatric vaccination with PCV13, and other associated epidemiological factors on the status of nasopharyngeal carriage, the circulating pneumococcal serotypes, and the antibiotic susceptibility to more frequently used antibiotics. Methods: A multi-center study was carried out in Primary Health Care, which included 1821 healthy children aged 1 to 4 years old. All isolates were sent to the Spanish Pneumococcal Reference Laboratory for serotyping and antimicrobial susceptibility testing. Results: At least one dose of PCV13 had been received by 71.9% of children and carriage pneumococcal prevalence was 19.7%. The proportion of PCV13 serotypes was low (14.4%), with an observed predominance of non-vaccine serotypes, 23B, 11A, 10A, 35B/F, and 23A were the five most frequent. A high rate of resistance to penicillin, erythromycin, and trimethoprim sulfamethoxazole was found. Conclusions: A low proportion of PCV13 serotypes were detected, confirming the impact of pediatric vaccination for reducing the serotypes vaccine carriage. High resistance rates to clinically important antibiotics were observed. View Full-Text
Keywords: Streptococcus pneumoniae nasopharyngeal carriage; conjugate vaccines; antimicrobial susceptibility Streptococcus pneumoniae nasopharyngeal carriage; conjugate vaccines; antimicrobial susceptibility
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MDPI and ACS Style

Alfayate Miguélez, S.; Yague Guirao, G.; Menasalvas Ruíz, A.I.; Sanchez-Solís, M.; Domenech Lucas, M.; González Camacho, F.; Ortíz Romero, M.M.; Espejo García, P.; Guerrero Gómez, C.; Iofrío de Arce, A.; Moreno Parrado, L.; Sánchez Andrada, R.M.; Cascales Alcolea, E.; Lorente García, S.; Paredes Reyes, P.; Casquet Barceló, Á.; López Yepes, M.L.; Vigueras Abellán, J.J.; Sanz Mateo, G.; Murcian Pneumococcal Study Group. Impact of Pneumococcal Vaccination in the Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children of the Murcia Region in Spain. Vaccines 2021, 9, 14. https://doi.org/10.3390/vaccines9010014

AMA Style

Alfayate Miguélez S, Yague Guirao G, Menasalvas Ruíz AI, Sanchez-Solís M, Domenech Lucas M, González Camacho F, Ortíz Romero MM, Espejo García P, Guerrero Gómez C, Iofrío de Arce A, Moreno Parrado L, Sánchez Andrada RM, Cascales Alcolea E, Lorente García S, Paredes Reyes P, Casquet Barceló Á, López Yepes ML, Vigueras Abellán JJ, Sanz Mateo G, Murcian Pneumococcal Study Group. Impact of Pneumococcal Vaccination in the Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children of the Murcia Region in Spain. Vaccines. 2021; 9(1):14. https://doi.org/10.3390/vaccines9010014

Chicago/Turabian Style

Alfayate Miguélez, Santiago; Yague Guirao, Genoveva; Menasalvas Ruíz, Ana I.; Sanchez-Solís, Manuel; Domenech Lucas, Mirian; González Camacho, Fernando; Ortíz Romero, M. M.; Espejo García, Pilar; Guerrero Gómez, Carmen; Iofrío de Arce, Antonio; Moreno Parrado, Laura; Sánchez Andrada, Rosa M.; Cascales Alcolea, Eva; Lorente García, Sebastián; Paredes Reyes, Pedro; Casquet Barceló, Ángela; López Yepes, M. L.; Vigueras Abellán, Juan J.; Sanz Mateo, Gonzalo; Murcian Pneumococcal Study Group. 2021. "Impact of Pneumococcal Vaccination in the Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children of the Murcia Region in Spain" Vaccines 9, no. 1: 14. https://doi.org/10.3390/vaccines9010014

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