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Article

Increasing Measles Seroprevalence in a Sample of Pediatric and Adolescent Population of Tuscany (Italy): A Vaccination Campaign Success

1
Department of Health Sciences, University of Florence, 50134 Florence, Italy
2
Medical Specialization School of Hygiene and Preventive Medicine, University of Florence, 50134 Florence, Italy
3
Meyer Children’s Hospital, 50139 Florence, Italy
4
AUSL Toscana Centro, 50122 Florence, Italy
*
Author to whom correspondence should be addressed.
Working Group DHS: Jacopo Bianchi, Ilaria Biondi, Martina Chellini, Gino Sartor, Maddalena Innocenti, Federico Manzi, Alessandra Ninci, Diana Paolini.
Working Group AOUMeyer: Francesco Puggelli, Paola Barbacci, Antonino Sala, Francesca Bellini, Roberto Schiatti, Sonia Muricci.
§
Working Group AUSLTC: Lorenzo Baggiani, Monica Della Fonte, Giorgio Garofalo, Giovanna Mereu, Simonetta Baretti, Maria Grazia Santini.
Vaccines 2020, 8(3), 512; https://doi.org/10.3390/vaccines8030512
Received: 30 July 2020 / Revised: 1 September 2020 / Accepted: 4 September 2020 / Published: 8 September 2020
(This article belongs to the Special Issue Measles-Mumps-Rubella-Varicella Vaccination)
Background: Despite the National Plan for the Elimination of Measles and congenital Rubella (NPEMcR), in 2017, a measles outbreak occurred in Italy, due to sub-optimal vaccination coverage (<95%) for many years. Since that year, the anti-measles vaccination became compulsory in minors (0–16 years) for school attendance. The aim of our study was to assess the immunity/susceptibility against measles in a representative sample of pediatric and adolescent (1–18 years) residents of the province of Florence (Tuscany, Italy), and to compare these results with two previous surveys (2003 and 2005–2006). Methods: The enzyme-linked immunosorbent assay (ELISA) was applied for a qualitative measurement of anti-measles antibodies on 165 sera. The anamnestic and vaccination status was also collected. Results: No measles notification was reported. The overall seropositivity was 88.5%; mostly in the 5–9 years old subjects (97.9%). Among the 152 vaccinated, 92.1% were positive. The seropositivity persisted after many years since the last dose of vaccine and tended to be more long-lasting in those who had received two or three doses. The susceptibility towards measles decreased over time, reaching a lower value in the current survey (8.5%) than in 2003 (30.8%) and in 2005–2006 (25.5%). Conclusions: This study confirmed the anti-measles vaccination campaign success, which allowed for the increase in vaccination coverage and immunity levels against measles in the Florentine pediatric and adolescent population following the NPEMcR implementation. View Full-Text
Keywords: measles; elimination; vaccination; pediatric; adolescence; seroprevalence; Italy; vaccination coverage; vaccination effectiveness; MMRV vaccination measles; elimination; vaccination; pediatric; adolescence; seroprevalence; Italy; vaccination coverage; vaccination effectiveness; MMRV vaccination
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MDPI and ACS Style

Zanella, B.; Boccalini, S.; Bonito, B.; Del Riccio, M.; Tiscione, E.; Bonanni, P.; Working Group DHS; Working Group AOUMeyer; Working Group AUSLTC; Bechini, A. Increasing Measles Seroprevalence in a Sample of Pediatric and Adolescent Population of Tuscany (Italy): A Vaccination Campaign Success. Vaccines 2020, 8, 512. https://doi.org/10.3390/vaccines8030512

AMA Style

Zanella B, Boccalini S, Bonito B, Del Riccio M, Tiscione E, Bonanni P, Working Group DHS, Working Group AOUMeyer, Working Group AUSLTC, Bechini A. Increasing Measles Seroprevalence in a Sample of Pediatric and Adolescent Population of Tuscany (Italy): A Vaccination Campaign Success. Vaccines. 2020; 8(3):512. https://doi.org/10.3390/vaccines8030512

Chicago/Turabian Style

Zanella, Beatrice, Sara Boccalini, Benedetta Bonito, Marco Del Riccio, Emilia Tiscione, Paolo Bonanni, Working Group DHS, Working Group AOUMeyer, Working Group AUSLTC, and Angela Bechini. 2020. "Increasing Measles Seroprevalence in a Sample of Pediatric and Adolescent Population of Tuscany (Italy): A Vaccination Campaign Success" Vaccines 8, no. 3: 512. https://doi.org/10.3390/vaccines8030512

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