Next Article in Journal
Exosomes: Biological Carriers and Promising Tools for Cancer Immunotherapy
Next Article in Special Issue
Recent Advances in the Development of Virus-Like Particle-Based Flavivirus Vaccines
Previous Article in Journal
Overexpression of VviPGIP1 and NtCAD14 in Tobacco Screened Using Glycan Microarrays Reveals Cell Wall Reorganisation in the Absence of Fungal Infection
Article

A Vaccine Displaying a Trimeric Influenza-A HA Stem Protein on Capsid-Like Particles Elicits Potent and Long-Lasting Protection in Mice

1
Department of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark
2
Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
3
AdaptVac Aps, Agern Alle 1, 2970 Hørsholm, Denmark
*
Author to whom correspondence should be addressed.
Vaccines 2020, 8(3), 389; https://doi.org/10.3390/vaccines8030389
Received: 22 June 2020 / Revised: 9 July 2020 / Accepted: 14 July 2020 / Published: 15 July 2020
(This article belongs to the Special Issue Virus-Like Particle & Nanoparticle Vaccines against Viral Infections)
Due to constant antigenic drift and shift, current influenza-A vaccines need to be redesigned and administered annually. A universal flu vaccine (UFV) that provides long-lasting protection against both seasonal and emerging pandemic influenza strains is thus urgently needed. The hemagglutinin (HA) stem antigen is a promising target for such a vaccine as it contains neutralizing epitopes, known to induce cross-protective IgG responses against a wide variety of influenza subtypes. In this study, we describe the development of a UFV candidate consisting of a HAstem trimer displayed on the surface of rigid capsid-like particles (CLP). Compared to soluble unconjugated HAstem trimer, the CLP-HAstem particles induced a more potent, long-lasting immune response and were able to protect mice against both homologous and heterologous H1N1 influenza challenge, even after a single dose. View Full-Text
Keywords: universal influenza vaccine; HA-stem antigen; capsid-like particles; Virus-like particles; trimer display; IgG2a; pandemic preparedness universal influenza vaccine; HA-stem antigen; capsid-like particles; Virus-like particles; trimer display; IgG2a; pandemic preparedness
Show Figures

Figure 1

MDPI and ACS Style

Thrane, S.; Aves, K.-L.; Uddbäck, I.E.M.; Janitzek, C.M.; Han, J.; Yang, Y.R.; Ward, A.B.; Theander, T.G.; Nielsen, M.A.; Salanti, A.; Thomsen, A.R.; Christensen, J.P.; Sander, A.F. A Vaccine Displaying a Trimeric Influenza-A HA Stem Protein on Capsid-Like Particles Elicits Potent and Long-Lasting Protection in Mice. Vaccines 2020, 8, 389. https://doi.org/10.3390/vaccines8030389

AMA Style

Thrane S, Aves K-L, Uddbäck IEM, Janitzek CM, Han J, Yang YR, Ward AB, Theander TG, Nielsen MA, Salanti A, Thomsen AR, Christensen JP, Sander AF. A Vaccine Displaying a Trimeric Influenza-A HA Stem Protein on Capsid-Like Particles Elicits Potent and Long-Lasting Protection in Mice. Vaccines. 2020; 8(3):389. https://doi.org/10.3390/vaccines8030389

Chicago/Turabian Style

Thrane, Susan; Aves, Kara-Lee; Uddbäck, Ida E.M.; Janitzek, Christoph M.; Han, Julianna; Yang, Yuhe R.; Ward, Andrew B.; Theander, Thor G.; Nielsen, Morten A.; Salanti, Ali; Thomsen, Allan R.; Christensen, Jan P.; Sander, Adam F. 2020. "A Vaccine Displaying a Trimeric Influenza-A HA Stem Protein on Capsid-Like Particles Elicits Potent and Long-Lasting Protection in Mice" Vaccines 8, no. 3: 389. https://doi.org/10.3390/vaccines8030389

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop