Primary Sjogren Syndrome: Focus on Innate Immune Cells and Inflammation
Abstract
:1. Introduction
2. Innate Immune Cells in pSS
2.1. Dendritic Cells (DCs)
2.2. Macrophages
2.3. Mast Cells
2.4. Salivary Gland Epithelial Cells (SGECs)
2.5. Endothelial Cells
2.6. Mucosa-Associated Invariant T (MAIT) Cells
2.7. Natural Killer Cells (NKs) and Natural Killer T Cells (NKTs)
2.8. Innate Lymphoid Cells (ILCs)
3. Main Mechanisms of Inflammation in pSS Related to Innate Immunity
3.1. IFN Signature, TLRs Activation, Intracellular Pathways Depending on JAK/STAT and MAP/ERK
3.2. Inflammasome
3.3. Non Coding RNAs (ncRNAs) and Their Epigenetic Effect
4. Conclusions
5. Future Perspectives
Author Contributions
Funding
Conflicts of Interest
References
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Rizzo, C.; Grasso, G.; Destro Castaniti, G.M.; Ciccia, F.; Guggino, G. Primary Sjogren Syndrome: Focus on Innate Immune Cells and Inflammation. Vaccines 2020, 8, 272. https://doi.org/10.3390/vaccines8020272
Rizzo C, Grasso G, Destro Castaniti GM, Ciccia F, Guggino G. Primary Sjogren Syndrome: Focus on Innate Immune Cells and Inflammation. Vaccines. 2020; 8(2):272. https://doi.org/10.3390/vaccines8020272
Chicago/Turabian StyleRizzo, Chiara, Giulia Grasso, Giulia Maria Destro Castaniti, Francesco Ciccia, and Giuliana Guggino. 2020. "Primary Sjogren Syndrome: Focus on Innate Immune Cells and Inflammation" Vaccines 8, no. 2: 272. https://doi.org/10.3390/vaccines8020272