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Advanced Foot-And-Mouth Disease Vaccine Platform for Stimulation of Simultaneous Cellular and Humoral Immune Responses

Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon-si, Gyeongsangbuk-do 39660, Korea
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Vaccines 2020, 8(2), 254; https://doi.org/10.3390/vaccines8020254
Received: 10 April 2020 / Revised: 16 May 2020 / Accepted: 25 May 2020 / Published: 28 May 2020
(This article belongs to the Special Issue Foot and Mouth Disease Virus and Novel Vaccines Developments)
Currently available commercial foot-and-mouth disease (FMD) vaccines have various limitations, such as the slow induction and short-term maintenance of antibody titers. Therefore, a novel FMD vaccine that can rapidly induce high neutralizing antibody titers to protect the host in early stages of an FMD virus infection, maintain high antibody titers for long periods after one vaccination dose, and confer full protection against clinical symptoms by simultaneously stimulating cellular and humoral immunity is needed. Here, we developed immunopotent FMD vaccine strains A-3A and A-HSP70, which elicit strong initial cellular immune response and induce humoral immune response, including long-lasting memory response. We purified the antigen (inactivated virus) derived from these immunopotent vaccine strains, and evaluated the immunogenicity and efficacy of the vaccines containing these antigens in mice and pigs. The immunopotent vaccine strains A-3A and A-HSP70 demonstrated superior immunogenicity compared with the A strain (backbone strain) in mice. The oil emulsion-free vaccine containing A-3A and A-HSP70 antigens effectively induced early, mid-term, and long-term immunity in mice and pigs by eliciting robust cellular and humoral immune responses through the activation of co-stimulatory molecules and the secretion of proinflammatory cytokines. We successfully derived an innovative FMD vaccine formulation to create more effective FMD vaccines. View Full-Text
Keywords: foot-and-mouth disease; vaccine; immunopotent; cellular and humoral immunity; protection foot-and-mouth disease; vaccine; immunopotent; cellular and humoral immunity; protection
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MDPI and ACS Style

Lee, M.J.; Jo, H.; Park, S.H.; Ko, M.-K.; Kim, S.-M.; Kim, B.; Park, J.-H. Advanced Foot-And-Mouth Disease Vaccine Platform for Stimulation of Simultaneous Cellular and Humoral Immune Responses. Vaccines 2020, 8, 254. https://doi.org/10.3390/vaccines8020254

AMA Style

Lee MJ, Jo H, Park SH, Ko M-K, Kim S-M, Kim B, Park J-H. Advanced Foot-And-Mouth Disease Vaccine Platform for Stimulation of Simultaneous Cellular and Humoral Immune Responses. Vaccines. 2020; 8(2):254. https://doi.org/10.3390/vaccines8020254

Chicago/Turabian Style

Lee, Min J., Hyundong Jo, So H. Park, Mi-Kyeong Ko, Su-Mi Kim, Byounghan Kim, and Jong-Hyeon Park. 2020. "Advanced Foot-And-Mouth Disease Vaccine Platform for Stimulation of Simultaneous Cellular and Humoral Immune Responses" Vaccines 8, no. 2: 254. https://doi.org/10.3390/vaccines8020254

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