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Subunit Vaccine Approaches for African Swine Fever Virus

Department of Diagnostic Medicine & Pathobiology, College of Veterinary Medicine, Kansas State University, K224 Mosier Hall, 1800 Denison Ave, Manhattan, KS 66506, USA
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Vaccines 2019, 7(2), 56; https://doi.org/10.3390/vaccines7020056
Received: 19 May 2019 / Revised: 21 June 2019 / Accepted: 21 June 2019 / Published: 25 June 2019
(This article belongs to the Special Issue Vaccines targeting African Swine Fever Virus)
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PDF [230 KB, uploaded 25 June 2019]

Abstract

African swine fever virus (ASFV) is the cause of a highly fatal disease in swine, for which there is no available vaccine. The disease is highly contagious and poses a serious threat to the swine industry worldwide. Since its introduction to the Caucasus region in 2007, a highly virulent, genotype II strain of ASFV has continued to circulate and spread into Eastern Europe and Russia, and most recently into Western Europe, China, and various countries of Southeast Asia. This review summarizes various ASFV vaccine strategies that have been investigated, with focus on antigen-, DNA-, and virus vector-based vaccines. Known ASFV antigens and the determinants of protection against ASFV versus immunopathological enhancement of infection and disease are also discussed. View Full-Text
Keywords: African swine fever virus; ASFV; vaccines; subunit vaccines; antigens; immunogens; protective immunity; disease enhancement; antibody dependent enhancement African swine fever virus; ASFV; vaccines; subunit vaccines; antigens; immunogens; protective immunity; disease enhancement; antibody dependent enhancement
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Gaudreault, N.N.; Richt, J.A. Subunit Vaccine Approaches for African Swine Fever Virus. Vaccines 2019, 7, 56.

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