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Vaccines 2018, 6(4), 73; https://doi.org/10.3390/vaccines6040073

Memory T Cells in Flavivirus Vaccination

1
,
1
and
1,2,3,4,*
1
Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
2
Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
3
Institute for Human Infections & Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA
4
Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA
*
Author to whom correspondence should be addressed.
Received: 16 August 2018 / Revised: 11 October 2018 / Accepted: 12 October 2018 / Published: 18 October 2018
(This article belongs to the Special Issue T Cell Memory to Vaccination)
Full-Text   |   PDF [241 KB, uploaded 18 October 2018]

Abstract

Flaviviruses include many medically important viruses, such as Dengue virus (DENV), Japanese encephalitis (JEV), tick-borne encephalitis (TBEV), West Nile (WNV), yellow fever (YFV), and Zika viruses (ZIKV). Currently, there are licensed human vaccines for DENV, JEV, TBEV and YFV, but not for WNV or ZIKV. Memory T cells play a central role in adaptive immunity and are important for host protection during flavivirus infection. In this review, we discuss recent findings from animal models and clinical trials and provide new insights into the role of memory T cells in host protective immunity upon vaccination with the licensed flavivirus vaccines. View Full-Text
Keywords: flavivirus; memory T cells; vaccine flavivirus; memory T cells; vaccine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Li, G.; Teleki, C.; Wang, T. Memory T Cells in Flavivirus Vaccination. Vaccines 2018, 6, 73.

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