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Vaccines 2018, 6(2), 34; https://doi.org/10.3390/vaccines6020034

Postgenomic Approaches and Bioinformatics Tools to Advance the Development of Vaccines against Bacteria of the Burkholderia cepacia Complex

IBB—Institute for Biotechnology and Biosciences, Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal
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Received: 11 May 2018 / Revised: 5 June 2018 / Accepted: 6 June 2018 / Published: 8 June 2018
(This article belongs to the Collection Vaccines Against Chronic and Persistent Bacterial Infections)
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Abstract

Bacteria of the Burkholderia cepacia complex (Bcc) remain an important cause of morbidity and mortality among patients suffering from cystic fibrosis. Eradication of these pathogens by antimicrobial therapy often fails, highlighting the need to develop novel strategies to eradicate infections. Vaccines are attractive since they can confer protection to particularly vulnerable patients, as is the case of cystic fibrosis patients. Several studies have identified specific virulence factors and proteins as potential subunit vaccine candidates. So far, no vaccine is available to protect from Bcc infections. In the present work, we review the most promising postgenomic approaches and selected web tools available to speed up the identification of immunogenic proteins with the potential of conferring protection against Bcc infections. View Full-Text
Keywords: Bcc vaccines; immunoproteomics; epitope prediction web tools Bcc vaccines; immunoproteomics; epitope prediction web tools
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Sousa, S.A.; Seixas, A.M.M.; Leitão, J.H. Postgenomic Approaches and Bioinformatics Tools to Advance the Development of Vaccines against Bacteria of the Burkholderia cepacia Complex. Vaccines 2018, 6, 34.

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