Next Article in Journal / Special Issue
New Kids on the Block: RNA-Based Influenza Virus Vaccines
Previous Article in Journal / Special Issue
Harnessing the Power of T Cells: The Promising Hope for a Universal Influenza Vaccine
Article Menu

Export Article

Open AccessReview
Vaccines 2018, 6(2), 19;

Efforts to Improve the Seasonal Influenza Vaccine

Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA
Author to whom correspondence should be addressed.
Received: 28 February 2018 / Revised: 26 March 2018 / Accepted: 27 March 2018 / Published: 30 March 2018
Full-Text   |   PDF [1150 KB, uploaded 30 March 2018]   |  


Influenza viruses infect approximately 20% of the global population annually, resulting in hundreds of thousands of deaths. While there are Food and Drug Administration (FDA) approved antiviral drugs for combating the disease, vaccination remains the best strategy for preventing infection. Due to the rapid mutation rate of influenza viruses, vaccine formulations need to be updated every year to provide adequate protection. In recent years, a great amount of effort has been focused on the development of a universal vaccine capable of eliciting broadly protective immunity. While universal influenza vaccines clearly have the best potential to provide long-lasting protection against influenza viruses, the timeline for their development, as well as the true universality of protection they afford, remains uncertain. In an attempt to reduce influenza disease burden while universal vaccines are developed and tested, many groups are working on a variety of strategies to improve the efficacy of the standard seasonal vaccine. This review will highlight the different techniques and technologies that have been, or are being, developed to improve the seasonal vaccination efforts against influenza viruses. View Full-Text
Keywords: influenza; seasonal vaccine; egg-adaptation; vaccine efficacy influenza; seasonal vaccine; egg-adaptation; vaccine efficacy

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Harding, A.T.; Heaton, N.S. Efforts to Improve the Seasonal Influenza Vaccine. Vaccines 2018, 6, 19.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Vaccines EISSN 2076-393X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top