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Egg-Independent Influenza Vaccines and Vaccine Candidates

Department of Molecular and Developmental Medicine, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
VisMederi S.r.l., Strada del Petriccio e Belriguardo 35, 53100 Siena, Italy
Author to whom correspondence should be addressed.
Academic Editor: Florian Krammer
Vaccines 2017, 5(3), 18;
Received: 8 June 2017 / Revised: 4 July 2017 / Accepted: 6 July 2017 / Published: 18 July 2017
PDF [564 KB, uploaded 18 July 2017]


Vaccination remains the principal way to control seasonal infections and is the most effective method of reducing influenza-associated morbidity and mortality. Since the 1940s, the main method of producing influenza vaccines has been an egg-based production process. However, in the event of a pandemic, this method has a significant limitation, as the time lag from strain isolation to final dose formulation and validation is six months. Indeed, production in eggs is a relatively slow process and production yields are both unpredictable and highly variable from strain to strain. In particular, if the next influenza pandemic were to arise from an avian influenza virus, and thus reduce the egg-laying hen population, there would be a shortage of embryonated eggs available for vaccine manufacturing. Although the production of egg-derived vaccines will continue, new technological developments have generated a cell-culture-based influenza vaccine and other more recent platforms, such as synthetic influenza vaccines. View Full-Text
Keywords: cell-culture; vaccination; synthetic influenza vaccine cell-culture; vaccination; synthetic influenza vaccine

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Manini, I.; Trombetta, C.M.; Lazzeri, G.; Pozzi, T.; Rossi, S.; Montomoli, E. Egg-Independent Influenza Vaccines and Vaccine Candidates. Vaccines 2017, 5, 18.

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