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Peptide Vaccine: Progress and Challenges

Department of Pathology, Midwestern University, Downers Grove, IL 60515, USA
Department of Pharmaceutical Sciences, Midwestern University, Downers Grove, IL 60515, USA
Symbiosis School of Biomedical Sciences, Symbiosis International University, Pune, MH 412115, India
Department of Microbiology and Immunology, Midwestern University, Downers Grove, IL 60515, USA
Author to whom correspondence should be addressed.
Vaccines 2014, 2(3), 515-536;
Received: 16 April 2014 / Revised: 10 June 2014 / Accepted: 13 June 2014 / Published: 2 July 2014
(This article belongs to the Special Issue Peptide Vaccine)
PDF [692 KB, uploaded 14 July 2014]


Conventional vaccine strategies have been highly efficacious for several decades in reducing mortality and morbidity due to infectious diseases. The bane of conventional vaccines, such as those that include whole organisms or large proteins, appear to be the inclusion of unnecessary antigenic load that, not only contributes little to the protective immune response, but complicates the situation by inducing allergenic and/or reactogenic responses. Peptide vaccines are an attractive alternative strategy that relies on usage of short peptide fragments to engineer the induction of highly targeted immune responses, consequently avoiding allergenic and/or reactogenic sequences. Conversely, peptide vaccines used in isolation are often weakly immunogenic and require particulate carriers for delivery and adjuvanting. In this article, we discuss the specific advantages and considerations in targeted induction of immune responses by peptide vaccines and progresses in the development of such vaccines against various diseases. Additionally, we also discuss the development of particulate carrier strategies and the inherent challenges with regard to safety when combining such technologies with peptide vaccines. View Full-Text
Keywords: peptide vaccine; epitope; adjuvants peptide vaccine; epitope; adjuvants

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Li, W.; Joshi, M.D.; Singhania, S.; Ramsey, K.H.; Murthy, A.K. Peptide Vaccine: Progress and Challenges. Vaccines 2014, 2, 515-536.

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