End-of-Season Influenza Vaccine Effectiveness Against Laboratory-Confirmed Influenza in Outpatient Settings, Beijing, China: A Test-Negative Design
Abstract
1. Introduction
2. Materials and Methods
2.1. Subject Enrollment and Laboratory Detection
2.2. Study Design and Data Collection
2.3. Statistical Analysis
3. Results
3.1. Study Population and Influenza Activity in the 2024–2025 Season
3.2. Phylogenetic Analysis
3.3. Influenza Vaccination Coverage and Vaccine Effectiveness Estimates
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Characteristic | Total, n (%) | Influenza-Positive Case, n (%) | Test-Negative Control, n (%) | p Value # | Vaccinated, n (%) | p Value # |
---|---|---|---|---|---|---|
Overall | 18,405 (100.0%) | 3690 (20.0%) | 14,715 (80.0%) | 2284 (12.4%) | ||
Age group | ||||||
0–5 years | 1850 (10.1%) | 295 (15.9%) | 1555 (84.1%) | <0.001 | 171 (9.2%) | <0.001 |
6–17 years | 4024 (21.9%) | 467 (11.6%) | 3557 (88.4%) | 1657 (41.2%) | ||
18–59 years | 10,563 (57.4%) | 2334 (22.1%) | 8229 (77.9%) | 231 (2.2%) | ||
≥60 years | 1968 (10.7%) | 594 (30.2%) | 1374 (69.8%) | 225 (11.4%) | ||
Sex | ||||||
Male | 8798 (47.8%) | 1748 (19.9%) | 7050 (80.1%) | 0.558 | 1159 (13.2%) | 0.003 |
Female | 9607 (52.2%) | 1942 (20.2%) | 7665 (79.8%) | 1125 (11.7%) | ||
Region * | ||||||
Urban | 8190 (44.5%) | 1717 (21.0%) | 6473 (79.0%) | <0.001 | 1004 (12.3%) | 0.463 |
Suburb | 6530 (35.5%) | 1186 (18.2%) | 5344 (81.8%) | 836 (12.8%) | ||
Exurban | 3685 (20.0%) | 787 (21.4%) | 2898 (78.6%) | 444 (12.0%) | ||
Chronic diseases | ||||||
Yes | 1144 (6.2%) | 273 (23.9%) | 871 (76.1%) | 0.001 | 74 (6.5%) | <0.001 |
No | 17,261 (93.8%) | 3417 (19.8%) | 13,844 (80.2%) | 2210 (12.8%) | ||
Influenza Status for the 2023/24 Season | ||||||
Uninfected | 9457 (51.4%) | 1951 (20.6%) | 7506 (79.4%) | 0.127 | 1197 (12.7%) | 0.232 |
Infection | 283 (1.5%) | 54 (19.1%) | 229 (80.9%) | 27 (9.5%) | ||
Unclear | 8665 (47.1%) | 1685 (19.4%) | 6980 (80.6%) | 1060 (12.2%) | ||
Pneumonia | ||||||
Yes | 912 (5.0%) | 105 (11.5%) | 807 (88.5%) | <0.001 | 104 (11.4%) | 0.344 |
No | 17,493 (95.0%) | 3585 (20.5%) | 13,908 (79.5%) | 2180 (12.5%) | ||
Interval between onset and sampling | ||||||
≤3 days | 17,531 (95.3%) | 3552 (20.3%) | 13,979 (79.7%) | <0.001 | 2175 (12.4%) | 0.955 |
4–7 days | 874 (4.7%) | 138 (15.8%) | 736 (84.2%) | 109 (12.5%) | ||
Epidemic period | ||||||
Pre-epidemic | 4651 (25.3%) | 255 (5.5%) | 4396 (94.5%) | <0.001 | 628 (13.5%) | 0.002 |
Epidemic | 7280 (39.6%) | 2885 (39.6%) | 4395 (60.4%) | 831 (11.4%) | ||
Post-epidemic | 6474 (35.2%) | 550 (8.5%) | 5924 (91.5%) | 825 (12.7%) | ||
Consecutive season vaccination | ||||||
Vaccinated (both seasons) | 1588 (8.6%) | 165 (10.4%) | 1423 (89.6%) | <0.001 | 1588 (100.0%) | - |
Vaccinated (2023/24 only) | 945 (5.1%) | 100 (10.6%) | 845 (89.4%) | 0 (0.0%) | ||
Vaccinated (2024/25 only) | 696 (3.8%) | 75 (10.8%) | 621 (89.2%) | 696 (100.0%) | ||
Unvaccinated (both seasons) | 15,176 (82.5%) | 3350 (22.1%) | 11,826 (77.9%) | 0 (0.0%) |
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Zhang, J.; Feng, Z.; Shen, Y.; Shi, W.; Sun, Y.; Zhao, J.; Wu, D.; Li, J.; Ma, C.; Duan, W.; et al. End-of-Season Influenza Vaccine Effectiveness Against Laboratory-Confirmed Influenza in Outpatient Settings, Beijing, China: A Test-Negative Design. Vaccines 2025, 13, 809. https://doi.org/10.3390/vaccines13080809
Zhang J, Feng Z, Shen Y, Shi W, Sun Y, Zhao J, Wu D, Li J, Ma C, Duan W, et al. End-of-Season Influenza Vaccine Effectiveness Against Laboratory-Confirmed Influenza in Outpatient Settings, Beijing, China: A Test-Negative Design. Vaccines. 2025; 13(8):809. https://doi.org/10.3390/vaccines13080809
Chicago/Turabian StyleZhang, Jiaojiao, Zhaomin Feng, Ying Shen, Weixian Shi, Ying Sun, Jiachen Zhao, Dan Wu, Jia Li, Chunna Ma, Wei Duan, and et al. 2025. "End-of-Season Influenza Vaccine Effectiveness Against Laboratory-Confirmed Influenza in Outpatient Settings, Beijing, China: A Test-Negative Design" Vaccines 13, no. 8: 809. https://doi.org/10.3390/vaccines13080809
APA StyleZhang, J., Feng, Z., Shen, Y., Shi, W., Sun, Y., Zhao, J., Wu, D., Li, J., Ma, C., Duan, W., Ma, J., Wang, Y., Zhang, L., Hu, X., Wang, Q., Zhang, D., & Yang, P. (2025). End-of-Season Influenza Vaccine Effectiveness Against Laboratory-Confirmed Influenza in Outpatient Settings, Beijing, China: A Test-Negative Design. Vaccines, 13(8), 809. https://doi.org/10.3390/vaccines13080809