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Volume 11
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10.3390/vaccines11020307
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Article

Efficacy of Oral Rabies Vaccine Baits Containing SPBN GASGAS in Domestic Dogs According to International Standards

by
Katharina Bobe
1,
Steffen Ortmann
1,
Christian Kaiser
2,
David Perez-Bravo
1,
Jörn Gethmann
3,
Jeannette Kliemt
4,
Sophia Körner
1,
Tobias Theuß
1,
Thomas Lindner
1,
Conrad Freuling
4,
Thomas Müller
4 and
Ad Vos
1,*
1
Ceva Innovation Center, Am Pharmapark, (D.P.-B. formerly: Institute of Epidemiology, Friedrich-Loeffler-Institute), 06861 Dessau-Rosslau, Germany
2
TEW Servicegesellschaft GmbH, Am Pharmapark, (C.K. formerly: Ceva Innovation Center), 06861 Dessau-Rosslau, Germany
3
Institute of Epidemiology, Friedrich-Loeffler-Institute, 17493 Greifswald-Insel Riems, Germany
4
Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institute, 17493 Greifswald-Insel Riems, Germany
*
Author to whom correspondence should be addressed.
Vaccines 2023, 11(2), 307; https://doi.org/10.3390/vaccines11020307
Submission received: 11 January 2023 / Revised: 27 January 2023 / Accepted: 27 January 2023 / Published: 30 January 2023
(This article belongs to the Special Issue Rabies Vaccines and Immunoglobulins)
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Abstract

(1) Background: The oral vaccination of free-roaming dogs against rabies has been developed as a promising complementary tool for mass dog vaccination. However, no oral rabies vaccine has provided efficacy data in dogs according to international standards. (2) Methods: To test the immunogenicity and efficacy of the third-generation oral rabies virus vaccine strain, SPBN GASGAS, in domestic dogs, dogs were offered an egg-flavoured bait containing 3.0 mL of the vaccine (107.5 FFU/mL) or a placebo egg-flavoured bait. Subsequently, these 25 vaccinated and 10 control animals were challenged approximately 6 months later with a dog rabies virus isolate. Blood samples were collected at different time points postvaccination and examined by ELISA and RFFIT. (3) Results: All but 1 of the 25 vaccinated dogs survived the challenge infection; meanwhile, all 10 control dogs succumbed to rabies. The serology results showed that all 25 vaccinated dogs seroconverted in ELISA (>40% PB); meanwhile, only 13 of the 25 vaccinated dogs tested seropositive ≥ 0.5 IU/mL) in RFFIT. (4) Conclusions: The SPBN GASGAS rabies virus vaccine meets the efficacy requirements for live oral rabies vaccines as laid down by the European Pharmacopoeia and the WOAH Terrestrial Manual. SPBN GASGAS already fulfilled the safety requirements for oral rabies vaccines targeted at dogs. Hence, the egg-flavoured bait containing SPBN GASGAS is the first oral vaccine bait that complies with WOAH recommendations for the intended use of oral vaccination of free-roaming dogs against rabies.
Keywords: dog; rabies; oral vaccination; challenge; efficacy study; SPBN GASGAS dog; rabies; oral vaccination; challenge; efficacy study; SPBN GASGAS

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MDPI and ACS Style

Bobe, K.; Ortmann, S.; Kaiser, C.; Perez-Bravo, D.; Gethmann, J.; Kliemt, J.; Körner, S.; Theuß, T.; Lindner, T.; Freuling, C.; et al. Efficacy of Oral Rabies Vaccine Baits Containing SPBN GASGAS in Domestic Dogs According to International Standards. Vaccines 2023, 11, 307. https://doi.org/10.3390/vaccines11020307

AMA Style

Bobe K, Ortmann S, Kaiser C, Perez-Bravo D, Gethmann J, Kliemt J, Körner S, Theuß T, Lindner T, Freuling C, et al. Efficacy of Oral Rabies Vaccine Baits Containing SPBN GASGAS in Domestic Dogs According to International Standards. Vaccines. 2023; 11(2):307. https://doi.org/10.3390/vaccines11020307

Chicago/Turabian Style

Bobe, Katharina, Steffen Ortmann, Christian Kaiser, David Perez-Bravo, Jörn Gethmann, Jeannette Kliemt, Sophia Körner, Tobias Theuß, Thomas Lindner, Conrad Freuling, and et al. 2023. "Efficacy of Oral Rabies Vaccine Baits Containing SPBN GASGAS in Domestic Dogs According to International Standards" Vaccines 11, no. 2: 307. https://doi.org/10.3390/vaccines11020307

APA Style

Bobe, K., Ortmann, S., Kaiser, C., Perez-Bravo, D., Gethmann, J., Kliemt, J., Körner, S., Theuß, T., Lindner, T., Freuling, C., Müller, T., & Vos, A. (2023). Efficacy of Oral Rabies Vaccine Baits Containing SPBN GASGAS in Domestic Dogs According to International Standards. Vaccines, 11(2), 307. https://doi.org/10.3390/vaccines11020307

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