Vaccine Coverage and Effectiveness in a School-Based Varicella Outbreak in Jinan Prefecture, Shandong Province
Abstract
:1. Introduction
2. Materials and Methods
2.1. Data Sources
2.2. Case Definition and Classification
2.3. Case Search
2.4. Statistical Analysis
2.5. Ethical Review
3. Results
3.1. School Information
3.2. Epidemiology of Cases
3.3. Varicella Vaccine Coverage
3.4. Vaccine Effectiveness
3.5. Public Health Response
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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N | Varicella Vaccination History | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
≥1 Dose | 1 Dose | 2 Doses | None | Unknown | ≥1 Dose (%) | Chi-square Trend | p | 2 Doses (%) | Chi-square Trend | p | ||
Eastern campus | ||||||||||||
Grade 1 | 1077 | 936 | 321 | 615 | 113 | 28 | 86.91 | 56.65 | 0.00 | 57.10 | 511.00 | 0.00 |
Grade 5 | 675 | 547 | 377 | 170 | 97 | 31 | 81.04 | 25.19 | ||||
Grade 6 | 445 | 343 | 254 | 89 | 47 | 55 | 77.08 | 20.00 | ||||
Grade 7 | 408 | 297 | 239 | 58 | 91 | 20 | 72.79 | 14.22 | ||||
Grade 8 | 339 | 257 | 215 | 42 | 70 | 12 | 75.81 | 12.39 | ||||
Subtotal | 2944 | 2380 | 1406 | 974 | 418 | 146 | 80.84 | 33.08 | ||||
Western campus (the affected school) | ||||||||||||
Grade 2 | 927 | 791 | 348 | 443 | 114 | 22 | 85.33 | 47.79 | ||||
Grade 3 | 846 | 678 | 370 | 308 | 113 | 55 | 80.14 | 36.41 | ||||
Grade 4 | 720 | 558 | 358 | 200 | 131 | 31 | 77.50 | 27.78 | ||||
Subtotal | 2493 | 2027 | 1076 | 951 | 358 | 108 | 81.31 | 38.15 | ||||
Total | 5437 | 4407 | 2482 | 1925 | 776 | 254 | 81.06 | 35.41 |
N | Varicella Vaccine History | History of Varicella Disease but Not Vaccinated | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
≥1 Dose | 1 Dose | 2 Doses | None | Unknown | ≥1 Dose (%) | 2 Doses (%) | Time Since Last Dose (Years) | |||
Class 1 | 45 | 33 | 20 | 13 | 11 | 1 | 73.33 | 28.89 | 8.98 | 3 |
Class 2 | 44 | 34 | 23 | 11 | 7 | 3 | 77.27 | 25.00 | 8.76 | 2 |
Class 3 | 45 | 35 | 22 | 13 | 7 | 3 | 77.78 | 28.89 | 8.58 | 1 |
Class 4 | 45 | 36 | 22 | 14 | 9 | 0 | 80.00 | 31.11 | 8.41 | 0 |
Class 5 | 44 | 31 | 23 | 8 | 10 | 3 | 70.45 | 18.18 | 8.82 | 2 |
Class 6 | 45 | 35 | 25 | 10 | 10 | 0 | 77.78 | 22.22 | 8.83 | 1 |
Class 7 | 46 | 34 | 24 | 10 | 12 | 0 | 73.91 | 21.74 | 9.12 | 3 |
Class 8 | 45 | 37 | 19 | 18 | 5 | 3 | 82.22 | 40.00 | 7.25 | 1 |
Total | 359 | 275 | 178 | 97 | 71 | 13 | 76.60 | 27.02 | 8.77 | 13 |
Doses | N | Case | Attack Rate (%) | RR (95%CI) | VE (%, 95%CI) |
---|---|---|---|---|---|
0 | 9 | 7 | 77.8 | ||
1 | 24 | 5 | 20.8 | 0.268 (0.114, 0.630) | 73.2% (37.0, 88.6) |
2 | 10 | 0 | 0.0 | 0 | 100% |
Total | 43 | 12 | 27.9 |
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Liu, X.; Li, Q.; Du, X.; Zhao, X.; Yin, Z. Vaccine Coverage and Effectiveness in a School-Based Varicella Outbreak in Jinan Prefecture, Shandong Province. Vaccines 2022, 10, 1225. https://doi.org/10.3390/vaccines10081225
Liu X, Li Q, Du X, Zhao X, Yin Z. Vaccine Coverage and Effectiveness in a School-Based Varicella Outbreak in Jinan Prefecture, Shandong Province. Vaccines. 2022; 10(8):1225. https://doi.org/10.3390/vaccines10081225
Chicago/Turabian StyleLiu, Xiaoxue, Quanxia Li, Xu Du, Xiaodong Zhao, and Zundong Yin. 2022. "Vaccine Coverage and Effectiveness in a School-Based Varicella Outbreak in Jinan Prefecture, Shandong Province" Vaccines 10, no. 8: 1225. https://doi.org/10.3390/vaccines10081225