Immunogenicity Following Two Doses of the BBIBP-CorV Vaccine and a Third Booster Dose with a Viral Vector and mRNA COVID-19 Vaccines against Delta and Omicron Variants in Prime Immunized Adults with Two Doses of the BBIBP-CorV Vaccine
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Population Study
2.2. Study Vaccines Interventions
2.3. Monitoring of Adverse Events
2.4. Laboratory Experiments
2.4.1. Immunoglobulin Assays
2.4.2. Surrogate Virus Neutralization Test (sVNT)
2.4.3. IFN-ɣ Releasing Assay
2.5. Statistical Analysis
3. Results
3.1. Antibody Responses against SARS-CoV-2 in the BBIBP-CorV-Primed Group
3.2. Antibody Responses against SARS-CoV-2 in the Third Dose with a Viral Vector or mRNA COVID-19 Vaccine Group
3.3. Surrogate Virus Neutralization Test
3.4. SARS-CoV-2 Stimulating IFN-ɣ CD4+/IFN-ɣ CD4+ and CD8+ T-Cell Response
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Chansaenroj, J.; Suntronwong, N.; Kanokudom, S.; Assawakosri, S.; Yorsaeng, R.; Vichaiwattana, P.; Klinfueng, S.; Wongsrisang, L.; Srimuan, D.; Thatsanatorn, T.; et al. Immunogenicity Following Two Doses of the BBIBP-CorV Vaccine and a Third Booster Dose with a Viral Vector and mRNA COVID-19 Vaccines against Delta and Omicron Variants in Prime Immunized Adults with Two Doses of the BBIBP-CorV Vaccine. Vaccines 2022, 10, 1071. https://doi.org/10.3390/vaccines10071071
Chansaenroj J, Suntronwong N, Kanokudom S, Assawakosri S, Yorsaeng R, Vichaiwattana P, Klinfueng S, Wongsrisang L, Srimuan D, Thatsanatorn T, et al. Immunogenicity Following Two Doses of the BBIBP-CorV Vaccine and a Third Booster Dose with a Viral Vector and mRNA COVID-19 Vaccines against Delta and Omicron Variants in Prime Immunized Adults with Two Doses of the BBIBP-CorV Vaccine. Vaccines. 2022; 10(7):1071. https://doi.org/10.3390/vaccines10071071
Chicago/Turabian StyleChansaenroj, Jira, Nungruthai Suntronwong, Sitthichai Kanokudom, Suvichada Assawakosri, Ritthideach Yorsaeng, Preeyaporn Vichaiwattana, Sirapa Klinfueng, Lakana Wongsrisang, Donchida Srimuan, Thaksaporn Thatsanatorn, and et al. 2022. "Immunogenicity Following Two Doses of the BBIBP-CorV Vaccine and a Third Booster Dose with a Viral Vector and mRNA COVID-19 Vaccines against Delta and Omicron Variants in Prime Immunized Adults with Two Doses of the BBIBP-CorV Vaccine" Vaccines 10, no. 7: 1071. https://doi.org/10.3390/vaccines10071071