Antigen Coverage Presented by MHC Class I Has a Negative Correlation with SARS-CoV-2-Induced Mortality
Abstract
:1. Introduction
2. Materials and Methods
2.1. Epidemiological Data
2.2. HLA Class I
2.3. T Cell Epitope Prediction for SARS-CoV-2
2.4. Antigen Coverage Calculation
3. Results
3.1. Antigen Coverage of SARS-CoV-2 Correlated with the Death Rate of COVID-19
3.2. Antigen Coverage Correlated Negatively with COVID-19 Mortality, in Contrast to Other Risk Factors
3.3. Effect of Antigen Coverage on the Mortality of COVID-19 and RNA Domains
3.4. Antigens Most Frequently Presented by HLAs
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Park, J.S.; Kim, K. Antigen Coverage Presented by MHC Class I Has a Negative Correlation with SARS-CoV-2-Induced Mortality. Vaccines 2022, 10, 1917. https://doi.org/10.3390/vaccines10111917
Park JS, Kim K. Antigen Coverage Presented by MHC Class I Has a Negative Correlation with SARS-CoV-2-Induced Mortality. Vaccines. 2022; 10(11):1917. https://doi.org/10.3390/vaccines10111917
Chicago/Turabian StylePark, Ji Soo, and Kwoneel Kim. 2022. "Antigen Coverage Presented by MHC Class I Has a Negative Correlation with SARS-CoV-2-Induced Mortality" Vaccines 10, no. 11: 1917. https://doi.org/10.3390/vaccines10111917
APA StylePark, J. S., & Kim, K. (2022). Antigen Coverage Presented by MHC Class I Has a Negative Correlation with SARS-CoV-2-Induced Mortality. Vaccines, 10(11), 1917. https://doi.org/10.3390/vaccines10111917