Oxidative Stress, Neuroinflammation and Mitochondria in the Pathophysiology of Amyotrophic Lateral Sclerosis
Abstract
:1. Introduction
2. Neuroinflammation and Oxidative Stress
3. Mitochondria and the Mechanism of Motor Neuron Death
4. Implications in the Therapy of ALS
5. Concluding Remarks
Author Contributions
Funding
Conflicts of Interest
References
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Motor Neurons | ||||||
---|---|---|---|---|---|---|
WT | FUS R521C | |||||
cyt | mt | Total | cyt | mt | Total | |
H2O2 (nmol/106 cells·min) | 0.42 ± 0.17 | 1.06 ± 0.33 ** | ||||
O2•− (ΔFL1, a.u.) | 2.11 ± 0.66 | 4.33 ± 1.20 * | ||||
Glutamate (nmol/106 cells) | 28.5 ± 4.3 | 5.6 ± 1.4 | 41.7 ± 5.9 ** | 7.2 ± 1.8 | ||
GSH (nmol/106 cells) | 21.2 ± 2.9 | 4.3 ± 1.2 | 15.0 ± 2.4 ** | 2.1 ± 0.5 ** | ||
GSSG (nmol/106 cells) | 0.5 ± 0.2 | 0.2 ± 0.05 | 1.0 ± 0.3 * | 0.4 ± 0.1 ** | ||
Ca2+ (nmol/mg protein) | 1087 ± 184 | 512 ± 96 | 1740 ± 260 ** | 826 ± 160 * |
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Obrador, E.; Salvador, R.; López-Blanch, R.; Jihad-Jebbar, A.; Vallés, S.L.; Estrela, J.M. Oxidative Stress, Neuroinflammation and Mitochondria in the Pathophysiology of Amyotrophic Lateral Sclerosis. Antioxidants 2020, 9, 901. https://doi.org/10.3390/antiox9090901
Obrador E, Salvador R, López-Blanch R, Jihad-Jebbar A, Vallés SL, Estrela JM. Oxidative Stress, Neuroinflammation and Mitochondria in the Pathophysiology of Amyotrophic Lateral Sclerosis. Antioxidants. 2020; 9(9):901. https://doi.org/10.3390/antiox9090901
Chicago/Turabian StyleObrador, Elena, Rosario Salvador, Rafael López-Blanch, Ali Jihad-Jebbar, Soraya L. Vallés, and José M. Estrela. 2020. "Oxidative Stress, Neuroinflammation and Mitochondria in the Pathophysiology of Amyotrophic Lateral Sclerosis" Antioxidants 9, no. 9: 901. https://doi.org/10.3390/antiox9090901