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Open AccessArticle

Modulating Laying Hens Productivity and Immune Performance in Response to Oxidative Stress Induced by E. coli Challenge Using Dietary Propolis Supplementation

1
Department of Animal and Fish Production, College of Agricultural and Food Sciences, King Faisal University, P.O. Box 420, Al-Ahsa 31982, Saudi Arabia
2
Department of Animal Production, Faculty of Agriculture, Cairo University, Gamma St., Giza, Cairo P.O. Box 12613, Egypt
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Department of Agricultural Biotechnology, College of Agricultural and Food Sciences, King Faisal University, P.O. Box 420, Al-Ahsa 31982, Saudi Arabia
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Department of Biochemistry, Faculty of Agriculture Cairo University, Gamma St., Giza, Cairo P.O. Box 12613, Egypt
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Department of Poultry breeding, Animal Production Research Institute, Agricultural Research Center, Dokki, Giza P.O. Box 12611, Egypt
6
Department of Animal Production, National Research Center, El Buhouth St., Dokki, Giza, Cairo P.O. Box 12622, Egypt
*
Authors to whom correspondence should be addressed.
Antioxidants 2020, 9(9), 893; https://doi.org/10.3390/antiox9090893
Received: 21 August 2020 / Revised: 17 September 2020 / Accepted: 18 September 2020 / Published: 21 September 2020
(This article belongs to the Special Issue Effect of Antioxidant Therapy on Oxidative Stress In Vivo)
Propolis (PR) is a resin product of bee colonies that has rich bioactive antioxidant and bactericidal compounds. Endotoxin, a byproduct of bacterial growth, is reported to cause progressive induction of endogenous oxidative stress and has negative impacts on individual health and wellbeing. Hereby, we investigated the ability of PR to alleviate the oxidative stress and immunosuppression imposed by avian pathogenic Escherichia coli using laying hen as a based model. In this study, PR was dietary supplemented to hens for 4 weeks at a concentration of 0.1%. At the beginning of the 4th week of the experiment, hens from control and PR treatment were injected with E. coli (O157:H7; 107 colonies/hen) or saline. The results showed significant (p < 0.05) negative impact of E. coli challenge on antioxidant status, immune response and productive performance. PR supplementation reduced (p < 0.05) inflammation markers levels (tumor necrosis factor α (TNFα) and interleukin 1β (IL-1β)) and plasma corticosterone concentration. The antioxidant status was ameliorated with dietary PR supplementation to challenged hens, showing significant (p < 0.05) reduction in malondialdehyde (MDA) levels and increasing total antioxidant capacity (TAC) concentrations. Cell mediated, as well as, humeral immune response improved significantly (p < 0.05) with dietary PR verified by the enhancement of T- and B-lymphocyte proliferation and the positive respond to phytohemagglutinin (PHA). Leucocyte cells viability increased significantly and the apoptotic factor forkhead box O3 (Foxo3) was reduced with PR supplementation. The current study revealed that dietary PR supplementation can effectively be used as an organic feed additive to overcome the endogenous oxidative stress induced by endotoxins challenge. View Full-Text
Keywords: propolis; E. coli; inflammation markers; lymphocyte proliferation; leucocyte cell viability; Foxo3; laying hen propolis; E. coli; inflammation markers; lymphocyte proliferation; leucocyte cell viability; Foxo3; laying hen
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MDPI and ACS Style

Abbas, A.O.; Alaqil, A.A.; El-Beltagi, H.S.; Abd El-Atty, H.K.; Kamel, N.N. Modulating Laying Hens Productivity and Immune Performance in Response to Oxidative Stress Induced by E. coli Challenge Using Dietary Propolis Supplementation. Antioxidants 2020, 9, 893. https://doi.org/10.3390/antiox9090893

AMA Style

Abbas AO, Alaqil AA, El-Beltagi HS, Abd El-Atty HK, Kamel NN. Modulating Laying Hens Productivity and Immune Performance in Response to Oxidative Stress Induced by E. coli Challenge Using Dietary Propolis Supplementation. Antioxidants. 2020; 9(9):893. https://doi.org/10.3390/antiox9090893

Chicago/Turabian Style

Abbas, Ahmed O.; Alaqil, Abdulaziz A.; El-Beltagi, Hossam S.; Abd El-Atty, Hanaa K.; Kamel, Nancy N. 2020. "Modulating Laying Hens Productivity and Immune Performance in Response to Oxidative Stress Induced by E. coli Challenge Using Dietary Propolis Supplementation" Antioxidants 9, no. 9: 893. https://doi.org/10.3390/antiox9090893

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