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Open AccessArticle

The Impact of Formulation on Lutein, Zeaxanthin, and meso-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled Study

1
Nutrition Research Centre Ireland, School of Health Sciences, Carriganore House, Waterford Institute of Technology West Campus, X91 X236 Waterford, Ireland
2
Teagasc Food Research Centre, Moorepark, Fermoy, P61 C996 Co. Cork, Ireland
*
Author to whom correspondence should be addressed.
Antioxidants 2020, 9(8), 767; https://doi.org/10.3390/antiox9080767
Received: 30 July 2020 / Revised: 14 August 2020 / Accepted: 15 August 2020 / Published: 18 August 2020
Lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) have been the focus of research and commercial interest for their applications in human health. Research into formulations to enhance their bioavailability is merited. This 6 month randomised placebo-controlled trial involving 81 healthy volunteers compared the bioavailability of different formulations of free L, Z, and MZ in sunflower or omega-3 oil versus L, Z, and MZ diacetates (Ld, Zd, and MZd) in a micromicellar formulation. Fasting serum carotenoids, macular pigment, and skin carotenoid score were analysed at baseline and 6 months. Serum L, Z, and MZ concentrations increased in all active interventions compared to placebo (p < 0.001 to p = 0.008). The diacetate micromicelle formulation exhibited a significantly higher mean response in serum concentrations of Z and MZ compared to the other active interventions (p = 0.002 to 0.019). A micromicellar formulation with solubilised Z and MZ diacetates is a promising technology advancement that enhances the bioavailability of these carotenoids when compared to traditional carotenoid formulations (ISRCTN clinical trial registration number: ISRCTN18206561). View Full-Text
Keywords: meso-zeaxanthin; zeaxanthin; lutein; carotenoid diacetates; bioavailability; micromicelles meso-zeaxanthin; zeaxanthin; lutein; carotenoid diacetates; bioavailability; micromicelles
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MDPI and ACS Style

Green-Gomez, M.; Prado-Cabrero, A.; Moran, R.; Power, T.; Gómez-Mascaraque, L.G.; Stack, J.; Nolan, J.M. The Impact of Formulation on Lutein, Zeaxanthin, and meso-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled Study. Antioxidants 2020, 9, 767. https://doi.org/10.3390/antiox9080767

AMA Style

Green-Gomez M, Prado-Cabrero A, Moran R, Power T, Gómez-Mascaraque LG, Stack J, Nolan JM. The Impact of Formulation on Lutein, Zeaxanthin, and meso-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled Study. Antioxidants. 2020; 9(8):767. https://doi.org/10.3390/antiox9080767

Chicago/Turabian Style

Green-Gomez, Marina; Prado-Cabrero, Alfonso; Moran, Rachel; Power, Tommy; Gómez-Mascaraque, Laura G.; Stack, Jim; Nolan, John M. 2020. "The Impact of Formulation on Lutein, Zeaxanthin, and meso-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled Study" Antioxidants 9, no. 8: 767. https://doi.org/10.3390/antiox9080767

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