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Open AccessReview

Polyphenols as Possible Agents for Pancreatic Diseases

1
Department of Plant Physiology, Institute for Biological Research “Siniša Stanković”, National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia
2
Innovation Center, University of Belgrade—Faculty of Chemistry, P.O. Box 51, 11158 Belgrade, Serbia
3
Clinic of Urology, Clinical Centre of Serbia, Pasterova 2, 11000 Belgrade, Serbia
4
University of Belgrade—Faculty of Medicine, dr Subotića 8, 11000 Belgrade, Serbia
5
First Surgical Clinic, Clinical Center of Serbia, Koste Todorovića 6, 11000 Belgrade, Serbia
6
Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia
7
University of Belgrade—Faculty of Chemistry, Studentski trg 12–16, P.O. Box 51, 11158 Belgrade, Serbia
*
Author to whom correspondence should be addressed.
Antioxidants 2020, 9(6), 547; https://doi.org/10.3390/antiox9060547
Received: 29 April 2020 / Revised: 26 May 2020 / Accepted: 31 May 2020 / Published: 23 June 2020
(This article belongs to the Special Issue Phenolics as Antioxidant Agents)
Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lines as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect. View Full-Text
Keywords: pancreatic diseases; polyphenols; synergistic effects; polyphenol bioavailability; quercetin; resveratrol pancreatic diseases; polyphenols; synergistic effects; polyphenol bioavailability; quercetin; resveratrol
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Gašić, U.; Ćirić, I.; Pejčić, T.; Radenković, D.; Djordjević, V.; Radulović, S.; Tešić, Ž. Polyphenols as Possible Agents for Pancreatic Diseases. Antioxidants 2020, 9, 547.

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