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Redox Signaling and Advanced Glycation Endproducts (AGEs) in Diet-Related Diseases

Departamento de Morfologia y Biologia Celular, Redox Biology Group, Universidad de Oviedo, 33403 Oviedo, Spain
Instituto Universitario de Oncologia del Principado de Asturias (IUOPA), Universidad de Oviedo, 33403 Oviedo, Spain
Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, 10125 Torino, Italy
Authors to whom correspondence should be addressed.
Antioxidants 2020, 9(2), 142;
Received: 15 December 2019 / Revised: 19 January 2020 / Accepted: 4 February 2020 / Published: 6 February 2020
Diets are currently characterized by elevated sugar intake, mainly due to the increased consumption of processed sweetened foods and drinks during the last 40 years. Diet is the main source of advanced glycation endproducts (AGEs). These are toxic compounds formed during the Maillard reaction, which takes place both in vivo, in tissues and fluids under physiological conditions, favored by sugar intake, and ex vivo during food preparation such as baking, cooking, frying or storage. Protein glycation occurs slowly and continuously through life, driving AGE accumulation in tissues during aging. For this reason, AGEs have been proposed as a risk factor in the pathogenesis of diet-related diseases such as diabetes, insulin resistance, cardiovascular diseases, kidney injury, and age-related and neurodegenerative diseases. AGEs are associated with an increase in oxidative stress since they mediate the production of reactive oxygen species (ROS), increasing the intracellular levels of hydrogen peroxide (H2O2), superoxide (O2), and nitric oxide (NO). The interaction of AGEs with the receptor for AGEs (RAGE) enhances oxidative stress through ROS production by NADPH oxidases inside the mitochondria. This affects mitochondrial function and ultimately influences cell metabolism under various pathological conditions. This short review will summarize all evidence that relates AGEs and ROS production, their relationship with diet-related diseases, as well as the latest research about the use of natural compounds with antioxidant properties to prevent the harmful effects of AGEs on health. View Full-Text
Keywords: advanced glycation products; RAGE; diet-related diseases; antioxidants advanced glycation products; RAGE; diet-related diseases; antioxidants
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Cepas, V.; Collino, M.; Mayo, J.C.; Sainz, R.M. Redox Signaling and Advanced Glycation Endproducts (AGEs) in Diet-Related Diseases. Antioxidants 2020, 9, 142.

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