Patent Review (2017–2020) of the Keap1/Nrf2 Pathway Using PatSeer Pro: Focus on Autoimmune Diseases
Abstract
:1. Introduction
2. Methods
3. Results and Discussion
3.1. The 509 Unique Nrf2-Related Patents Published between January 2017 and May 2020
3.2. Autoimmune and Oxidative Stress-Related Pathologies Are Main Topics of Nrf2-Related Patents
3.3. Overview of Nrf2-Related Patents in Autoimmune Diseases
4. Conclusions
Supplementary Materials
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
ARE | antioxidant response element |
CDDO-Me | C-28 methyl ester of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid |
COPD | chronic obstructive pulmonary disease |
EAE | experimental autoimmune encephalomyelitis |
HIF1 | hypoxia-inducible factor 1 |
IBD | inflammatory bowel disease |
Keap1 | Kelch-like ECH-associated protein 1 |
MS | multiple sclerosis |
Nfe2l2 | nuclear factor erythroid 2-like factor 2 |
Nrf2 | nuclear factor erythroid 2-related factor 2 |
PGK1 | phosphoglycerate kinase 1 |
RA | rheumatoid arthritis |
SCID | severe combined immunodeficiency |
SjS | Sjögren’s syndrome |
SLE | systemic lupus erythematosus |
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Chartoumpekis, D.V.; Fu, C.-Y.; Ziros, P.G.; Sykiotis, G.P. Patent Review (2017–2020) of the Keap1/Nrf2 Pathway Using PatSeer Pro: Focus on Autoimmune Diseases. Antioxidants 2020, 9, 1138. https://doi.org/10.3390/antiox9111138
Chartoumpekis DV, Fu C-Y, Ziros PG, Sykiotis GP. Patent Review (2017–2020) of the Keap1/Nrf2 Pathway Using PatSeer Pro: Focus on Autoimmune Diseases. Antioxidants. 2020; 9(11):1138. https://doi.org/10.3390/antiox9111138
Chicago/Turabian StyleChartoumpekis, Dionysios V., Chun-Yan Fu, Panos G. Ziros, and Gerasimos P. Sykiotis. 2020. "Patent Review (2017–2020) of the Keap1/Nrf2 Pathway Using PatSeer Pro: Focus on Autoimmune Diseases" Antioxidants 9, no. 11: 1138. https://doi.org/10.3390/antiox9111138