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Open AccessArticle

A Combination of Rosa Canina Extracts and Gold Complex Favors Apoptosis of Caco-2 Cells by Increasing Oxidative Stress and Mitochondrial Dysfunction

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Department of Pharmacology and Physiology, Veterinary Faculty, University of Zaragoza, 50009 Zaragoza, Spain
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Department of Science, Public University of Navarra, INAMAT, 31006 Pamplona, Spain
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Department of Biochemistry and Molecular Biology, Veterinary Faculty, University of Zaragoza, 50009 Zaragoza, Spain
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Centro de Investigación Biomédica en Red - Obesidad y Nutrición (CIBERobn) (ISCIII), IIS Aragón, IA2, 50009 Zaragoza, Spain
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Department of Inorganic Chemistry, Sciences Faculty, University of Zaragoza, 50009 Zaragoza, Spain
*
Authors to whom correspondence should be addressed.
Antioxidants 2020, 9(1), 17; https://doi.org/10.3390/antiox9010017
Received: 4 November 2019 / Revised: 19 December 2019 / Accepted: 20 December 2019 / Published: 24 December 2019
(This article belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)
Given the alarming increase in colorectal cancer (CRC) worldwide, novel therapies are urgently needed. Plant-derived extracts have gained considerable interest in the last years due to their strong anticancer effect mediated by their unique bioactive compounds. Specifically, rosehips from Rosa canina have been successfully tested against several cancer models, including colon cancer. Moreover, gold derivatives are a promising alternative to the current platinum-based drugs commonly used in CRC chemotherapy due to their lack of affinity for DNA. Herein we have investigated the antitumor potential of a drug combination made of acidic polyphenols extracted from R. canina and the gold complex (Au(C≡C-2-NC5H4) (PTA)) in Caco-2 cell line as a model of CRC. The combination triggered strong apoptosis mediated by a blockage of the autophagic flux, which might be a consequence of a reactive oxygen species (ROS) increase and mitochondrial dysfunctionality. Our results suggest that the clinical application of plant polyphenols might enhance the anticancer effect of metallodrugs and reduce drug exposure time and therefore its side effects. View Full-Text
Keywords: apoptosis; autophagy; colorectal cancer; rosehip; gold complex; ROS apoptosis; autophagy; colorectal cancer; rosehip; gold complex; ROS
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MDPI and ACS Style

Mármol, I.; Jiménez-Moreno, N.; Ancín-Azpilicueta, C.; Osada, J.; Cerrada, E.; Rodríguez-Yoldi, M.J. A Combination of Rosa Canina Extracts and Gold Complex Favors Apoptosis of Caco-2 Cells by Increasing Oxidative Stress and Mitochondrial Dysfunction. Antioxidants 2020, 9, 17.

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