Next Article in Journal
LC-ESI-QTOF/MS Characterisation of Phenolic Acids and Flavonoids in Polyphenol-Rich Fruits and Vegetables and Their Potential Antioxidant Activities
Next Article in Special Issue
Nitric Oxide-Mediated Enhancement and Reversal of Resistance of Anticancer Therapies
Previous Article in Journal
The Role of Heme Oxygenase-1 in Remote Ischemic and Anesthetic Organ Conditioning

S-Nitrosylation: An Emerging Paradigm of Redox Signaling

Department of Cancer Biology, University of Toledo Health Science Campus, 3000 Arlington Ave., Toledo, OH 43614, USA
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(9), 404;
Received: 27 August 2019 / Revised: 12 September 2019 / Accepted: 13 September 2019 / Published: 17 September 2019
(This article belongs to the Special Issue NO(NOx) and H2S)
Nitric oxide (NO) is a highly reactive molecule, generated through metabolism of L-arginine by NO synthase (NOS). Abnormal NO levels in mammalian cells are associated with multiple human diseases, including cancer. Recent studies have uncovered that the NO signaling is compartmentalized, owing to the localization of NOS and the nature of biochemical reactions of NO, including S-nitrosylation. S-nitrosylation is a selective covalent post-translational modification adding a nitrosyl group to the reactive thiol group of a cysteine to form S-nitrosothiol (SNO), which is a key mechanism in transferring NO-mediated signals. While S-nitrosylation occurs only at select cysteine thiols, such a spatial constraint is partially resolved by transnitrosylation, where the nitrosyl moiety is transferred between two interacting proteins to successively transfer the NO signal to a distant location. As NOS is present in various subcellular locales, a stress could trigger concerted S-nitrosylation and transnitrosylation of a large number of proteins involved in divergent signaling cascades. S-nitrosylation is an emerging paradigm of redox signaling by which cells confer protection against oxidative stress. View Full-Text
Keywords: NO; S-nitrosylation; NOS; ROS; antioxidant; redox regulation NO; S-nitrosylation; NOS; ROS; antioxidant; redox regulation
Show Figures

Figure 1

MDPI and ACS Style

Fernando, V.; Zheng, X.; Walia, Y.; Sharma, V.; Letson, J.; Furuta, S. S-Nitrosylation: An Emerging Paradigm of Redox Signaling. Antioxidants 2019, 8, 404.

AMA Style

Fernando V, Zheng X, Walia Y, Sharma V, Letson J, Furuta S. S-Nitrosylation: An Emerging Paradigm of Redox Signaling. Antioxidants. 2019; 8(9):404.

Chicago/Turabian Style

Fernando, Veani, Xunzhen Zheng, Yashna Walia, Vandana Sharma, Joshua Letson, and Saori Furuta. 2019. "S-Nitrosylation: An Emerging Paradigm of Redox Signaling" Antioxidants 8, no. 9: 404.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop