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Comment published on 15 February 2019, see Antioxidants 2019, 8(2), 42.

Open AccessArticle

Healthcare Workers Occupationally Exposed to Ionizing Radiation Exhibit Altered Levels of Inflammatory Cytokines and Redox Parameters

1
Department of Medical Imaging and Therapeutic Sciences, College of Allied Health Professions, University of Nebraska Medical Center (UNMC), Omaha, NE 68198, USA
2
Department of Pathology and Microbiology, College of Medicine, UNMC, Omaha, NE 68198, USA
3
College of Nursing, UNMC, Omaha, NE 68198, USA
4
Department of Cellular and Integrative Physiology, College of Medicine, UNMC, Omaha, NE 68198, USA
*
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(1), 12; https://doi.org/10.3390/antiox8010012
Received: 23 October 2018 / Revised: 21 December 2018 / Accepted: 24 December 2018 / Published: 1 January 2019
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Abstract

Studies have shown an increased risk for a variety of cancers, specifically brain cancer, in healthcare workers occupationally exposed to ionizing radiation. Although the mechanisms mediating these phenomena are not fully understood, ionizing radiation-mediated elevated levels of reactive oxygen species (ROS), oxidative DNA damage, and immune modulation are likely involved. A group of 20 radiation exposed workers and 40 sex- and age-matched non-exposed control subjects were recruited for the study. We measured superoxide (O2) levels in whole blood of healthcare workers and all other measurements of cytokines, oxidative DNA damage, extracellular superoxide dismutase (EcSOD) activity and reduced/oxidized glutathione ratio (GSH/GSSG) in plasma. Levels of O2 were significantly higher in radiation exposed workers compared to control. Similarly, a significant increase in the levels of interleukin (IL)-6, IL-1α and macrophage inflammatory protein (MIP)-1α in radiation exposed workers compared to control was observed, while there was no significance difference in the other 27 screened cytokines. A significant positive correlation was found between MIP-1α and O2 levels with no correlation in either IL-6 or IL-1α. Further, a dose-dependent relationship with significant O2 production and immune alterations in radiation exposed workers was demonstrated. There was no statistical difference between the groups in terms of oxidative DNA damage, GSH/GSSG levels, or EcSOD activity. Although the biologic significance of cytokines alterations in radiation exposed workers is unclear, further studies are needed for determining the underlying mechanism of their elevation. View Full-Text
Keywords: O2; EcSOD; inflammatory cytokines; oxidative stress; DNA oxidation; glutathione O2; EcSOD; inflammatory cytokines; oxidative stress; DNA oxidation; glutathione
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Ahmad, I.M.; Abdalla, M.Y.; Moore, T.A.; Bartenhagen, L.; Case, A.J.; Zimmerman, M.C. Healthcare Workers Occupationally Exposed to Ionizing Radiation Exhibit Altered Levels of Inflammatory Cytokines and Redox Parameters. Antioxidants 2019, 8, 12.

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