Antioxidants 2018, 7(4), 46; https://doi.org/10.3390/antiox7040046
Polymeric Nanoparticles for Increasing Oral Bioavailability of Curcumin
Anita Umerska 1
, Caroline Gaucher 1,*
, Felipe Oyarzun-Ampuero 2, Isabelle Fries-Raeth 1, Florence Colin 1, María Gabriela Villamizar-Sarmiento 2, Philippe Maincent 1 and Anne Sapin-Minet 1
, Caroline Gaucher 1,*
, Felipe Oyarzun-Ampuero 2, Isabelle Fries-Raeth 1, Florence Colin 1, María Gabriela Villamizar-Sarmiento 2, Philippe Maincent 1 and Anne Sapin-Minet 11
Université de Lorraine, CITHEFOR, F-54000 Nancy, France
2
Departamento de Ciencias y Tecnología Farmacéuticas, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, 758-0150 Santiago, Chile
*
Author to whom correspondence should be addressed.
Received: 27 February 2018 / Revised: 19 March 2018 / Accepted: 22 March 2018 / Published: 24 March 2018
(This article belongs to the Special Issue Inspired by Nature: Antioxidants and Nanotechnology)
Abstract
Despite the promising biological and antioxidant properties of curcumin, its medical applications are limited due to poor solubility in water and low bioavailability. Polymeric nanoparticles (NPs) adapted to oral delivery may overcome these drawbacks. Properties such as particle size, zeta potential, morphology and encapsulation efficiency were assessed. Then, the possibility of storing these NPs in a solid-state form obtained by freeze-drying, in vitro curcumin dissolution and cytocompatibility towards intestinal cells were evaluated. Curcumin-loaded Eudragit® RLPO (ERL) NPs showed smaller particle diameters (245 ± 2 nm) and better redispersibility after freeze-drying than either poly(lactic-co-glycolic acid) (PLGA) or polycaprolactone (PCL) NPs. The former NPs showed lower curcumin encapsulation efficiency (62%) than either PLGA or PCL NPs (90% and 99%, respectively). Nevertheless, ERL NPs showed rapid curcumin release with 91 ± 5% released over 1 h. The three curcumin-loaded NPs proposed in this work were also compatible with intestinal cells. Overall, ERL NPs are the most promising vehicles for increasing the oral bioavailability of curcumin. View Full-TextKeywords:
curcumin; nanoparticles; PLGA; PCL; Eudragit; cytocompatibility; intestinal cells; single emulsion-solvent evaporation method
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Umerska, A.; Gaucher, C.; Oyarzun-Ampuero, F.; Fries-Raeth, I.; Colin, F.; Villamizar-Sarmiento, M.G.; Maincent, P.; Sapin-Minet, A. Polymeric Nanoparticles for Increasing Oral Bioavailability of Curcumin. Antioxidants 2018, 7, 46.
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