Next Article in Journal
Effect of Extract and Ellagic Acid from Geranium schiedeanum on the Antioxidant Defense System in An Induced-Necrosis Model
Next Article in Special Issue
Peroxiredoxins in Cancer and Response to Radiation Therapies
Previous Article in Journal
Analysis of Protein Oxidative Modifications in Follicular Fluid from Fertile Women: Natural Versus Stimulated Cycles
Previous Article in Special Issue
Cancer-Associated Function of 2-Cys Peroxiredoxin Subtypes as a Survival Gatekeeper
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessReview

Piecing Together How Peroxiredoxins Maintain Genomic Stability

Biochemistry & Molecular Biology Program, Departments of Biology and Chemistry, The College of Wooster, Wooster, OH 44691, USA
Author to whom correspondence should be addressed.
Antioxidants 2018, 7(12), 177;
Received: 31 October 2018 / Revised: 21 November 2018 / Accepted: 24 November 2018 / Published: 28 November 2018
(This article belongs to the Special Issue The Role of Peroxiredoxins in Cancer)
PDF [2952 KB, uploaded 28 November 2018]


Peroxiredoxins, a highly conserved family of thiol oxidoreductases, play a key role in oxidant detoxification by partnering with the thioredoxin system to protect against oxidative stress. In addition to their peroxidase activity, certain types of peroxiredoxins possess other biochemical activities, including assistance in preventing protein aggregation upon exposure to high levels of oxidants (molecular chaperone activity), and the transduction of redox signals to downstream proteins (redox switch activity). Mice lacking the peroxiredoxin Prdx1 exhibit an increased incidence of tumor formation, whereas baker’s yeast (Saccharomyces cerevisiae) lacking the orthologous peroxiredoxin Tsa1 exhibit a mutator phenotype. Collectively, these findings suggest a potential link between peroxiredoxins, control of genomic stability, and cancer etiology. Here, we examine the potential mechanisms through which Tsa1 lowers mutation rates, taking into account its diverse biochemical roles in oxidant defense, protein homeostasis, and redox signaling as well as its interplay with thioredoxin and thioredoxin substrates, including ribonucleotide reductase. More work is needed to clarify the nuanced mechanism(s) through which this highly conserved peroxidase influences genome stability, and to determine if this mechanism is similar across a range of species. View Full-Text
Keywords: peroxiredoxin; oxidative stress; thioredoxin; thiol peroxidase; mutator; genomic instability; sulfiredoxin; redox switch; ribonucleotide reductase peroxiredoxin; oxidative stress; thioredoxin; thiol peroxidase; mutator; genomic instability; sulfiredoxin; redox switch; ribonucleotide reductase

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

West, J.D.; Roston, T.J.; David, J.B.; Allan, K.M.; Loberg, M.A. Piecing Together How Peroxiredoxins Maintain Genomic Stability. Antioxidants 2018, 7, 177.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top