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Antioxidants 2018, 7(11), 165;

Structural/Functional Matches and Divergences of Phytoprostanes and Phytofurans with Bioactive Human Oxylipins

CQM—Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal
Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), Campus University Espinardo, 30100 Murcia, Spain
Institut des Biomolécules Max Mousseron (IBMM), UMR 5247—CNRS, Faculty of Pharmacy, University of Montpellier—ENSCM, 34093 Montpellier, France
Author to whom correspondence should be addressed.
Received: 16 October 2018 / Revised: 13 November 2018 / Accepted: 14 November 2018 / Published: 16 November 2018
(This article belongs to the Special Issue Lipid Peroxidation: Analysis and Applications in Biological Systems)
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Structure-activity relationship (SAR) constitutes a crucial topic to discover new bioactive molecules. This approach initiates with the comparison of a target candidate with a molecule or a collection of molecules and their attributed biological functions to shed some light in the details of one or more SARs and subsequently using that information to outline valuable application of the newly identified compounds. Thus, while the empiric knowledge of medicinal chemistry is critical to these tasks, the results retrieved upon dedicated experimental demonstration retrieved resorting to modern high throughput analytical approaches and techniques allow to overwhelm the constraints adduced so far to the successful accomplishment of such tasks. Therefore, the present work reviews critically the evidences reported to date on the occurrence of phytoprostanes and phytofurans in plant foods, and the information available on their bioavailability and biological activity, shedding some light on the expectation waken up due to their structural similarities with prostanoids and isoprostanes. View Full-Text
Keywords: plant oxylipins; mammals oxylipins; structural analogy; biological activity; SAR plant oxylipins; mammals oxylipins; structural analogy; biological activity; SAR

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Medina, S.; Gil-Izquierdo, Á.; Durand, T.; Ferreres, F.; Domínguez-Perles, R. Structural/Functional Matches and Divergences of Phytoprostanes and Phytofurans with Bioactive Human Oxylipins. Antioxidants 2018, 7, 165.

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