Next Article in Journal
Crystal Structure of the Apo-Form of NADPH-Dependent Thioredoxin Reductase from a Methane-Producing Archaeon
Next Article in Special Issue
Oxidative Stress in the Newborn Period: Useful Biomarkers in the Clinical Setting
Previous Article in Journal
Characterization of TrxC, an Atypical Thioredoxin Exclusively Present in Cyanobacteria
Previous Article in Special Issue
Profiling of Omega-Polyunsaturated Fatty Acids and Their Oxidized Products in Salmon after Different Cooking Methods
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessReview
Antioxidants 2018, 7(11), 165; https://doi.org/10.3390/antiox7110165

Structural/Functional Matches and Divergences of Phytoprostanes and Phytofurans with Bioactive Human Oxylipins

1
CQM—Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal
2
Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), Campus University Espinardo, 30100 Murcia, Spain
3
Institut des Biomolécules Max Mousseron (IBMM), UMR 5247—CNRS, Faculty of Pharmacy, University of Montpellier—ENSCM, 34093 Montpellier, France
*
Author to whom correspondence should be addressed.
Received: 16 October 2018 / Revised: 13 November 2018 / Accepted: 14 November 2018 / Published: 16 November 2018
(This article belongs to the Special Issue Lipid Peroxidation: Analysis and Applications in Biological Systems)
Full-Text   |   PDF [1106 KB, uploaded 16 November 2018]   |  

Abstract

Structure-activity relationship (SAR) constitutes a crucial topic to discover new bioactive molecules. This approach initiates with the comparison of a target candidate with a molecule or a collection of molecules and their attributed biological functions to shed some light in the details of one or more SARs and subsequently using that information to outline valuable application of the newly identified compounds. Thus, while the empiric knowledge of medicinal chemistry is critical to these tasks, the results retrieved upon dedicated experimental demonstration retrieved resorting to modern high throughput analytical approaches and techniques allow to overwhelm the constraints adduced so far to the successful accomplishment of such tasks. Therefore, the present work reviews critically the evidences reported to date on the occurrence of phytoprostanes and phytofurans in plant foods, and the information available on their bioavailability and biological activity, shedding some light on the expectation waken up due to their structural similarities with prostanoids and isoprostanes. View Full-Text
Keywords: plant oxylipins; mammals oxylipins; structural analogy; biological activity; SAR plant oxylipins; mammals oxylipins; structural analogy; biological activity; SAR
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Medina, S.; Gil-Izquierdo, Á.; Durand, T.; Ferreres, F.; Domínguez-Perles, R. Structural/Functional Matches and Divergences of Phytoprostanes and Phytofurans with Bioactive Human Oxylipins. Antioxidants 2018, 7, 165.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top