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Antioxidants
Volume 14
Issue 12
10.3390/antiox14121401
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Hyperoside Promotes Mitochondrial Autophagy Through the miR-361-5p/PI3K/Akt/mTOR Signaling Pathway, Thereby Improving UVB-Induced Photoaging

by
Danni Yang
1,
Jiayi Le
1,
Shuyun Xiao
1,
Yulin Cui
1,
Wanfang Zhu
2,
Kouharu Otsuki
3,
Wei Li
3,
Jian Xu
1,
Feng Feng
1 and
Jie Zhang
1,*
1
School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China
2
College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130022, China
3
Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan
*
Author to whom correspondence should be addressed.
Antioxidants 2025, 14(12), 1401; https://doi.org/10.3390/antiox14121401
Submission received: 23 October 2025 / Revised: 20 November 2025 / Accepted: 21 November 2025 / Published: 25 November 2025
Versions Notes

Abstract

Ultraviolet radiation B (UVB) radiation can induce oxidative stress, DNA damage, and inflammation, leading to skin wrinkling, impaired barrier function, and an increased risk of cancer. Addressing or preventing photoaging may provide a promising therapeutic avenue for these conditions. Hyperoside (HY), a compound abundantly found in medicinal plants including Hypericum perforatum and Crataegus, has been reported to have various pharmacological activities such as antioxidant, anti-inflammatory, cytoprotective, and antitumor effects; however, there are currently no studies systematically exploring the potential and mechanisms of HY in alleviating skin damage caused by ultraviolet (UV) rays. We investigated the inhibitory effects of HY on oxidative stress responses, reducing keratinocyte aging. HY can also exert these effects by mediating the PI3K/AKT/mTOR signaling pathway through miR-361-5p, maintaining mitochondrial dynamic stability, alleviating mitochondrial dysfunction, and enhancing mitophagy. Additionally, in vivo, HY was able to significantly improve skin wrinkles in mice while reducing changes in thickness and aging of the epidermis and dermis.
Keywords: photoaging; hyperoside; miRNA; PI3K/Akt/mTOR; mitophagy photoaging; hyperoside; miRNA; PI3K/Akt/mTOR; mitophagy

Share and Cite

MDPI and ACS Style

Yang, D.; Le, J.; Xiao, S.; Cui, Y.; Zhu, W.; Otsuki, K.; Li, W.; Xu, J.; Feng, F.; Zhang, J. Hyperoside Promotes Mitochondrial Autophagy Through the miR-361-5p/PI3K/Akt/mTOR Signaling Pathway, Thereby Improving UVB-Induced Photoaging. Antioxidants 2025, 14, 1401. https://doi.org/10.3390/antiox14121401

AMA Style

Yang D, Le J, Xiao S, Cui Y, Zhu W, Otsuki K, Li W, Xu J, Feng F, Zhang J. Hyperoside Promotes Mitochondrial Autophagy Through the miR-361-5p/PI3K/Akt/mTOR Signaling Pathway, Thereby Improving UVB-Induced Photoaging. Antioxidants. 2025; 14(12):1401. https://doi.org/10.3390/antiox14121401

Chicago/Turabian Style

Yang, Danni, Jiayi Le, Shuyun Xiao, Yulin Cui, Wanfang Zhu, Kouharu Otsuki, Wei Li, Jian Xu, Feng Feng, and Jie Zhang. 2025. "Hyperoside Promotes Mitochondrial Autophagy Through the miR-361-5p/PI3K/Akt/mTOR Signaling Pathway, Thereby Improving UVB-Induced Photoaging" Antioxidants 14, no. 12: 1401. https://doi.org/10.3390/antiox14121401

APA Style

Yang, D., Le, J., Xiao, S., Cui, Y., Zhu, W., Otsuki, K., Li, W., Xu, J., Feng, F., & Zhang, J. (2025). Hyperoside Promotes Mitochondrial Autophagy Through the miR-361-5p/PI3K/Akt/mTOR Signaling Pathway, Thereby Improving UVB-Induced Photoaging. Antioxidants, 14(12), 1401. https://doi.org/10.3390/antiox14121401

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