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Article

Agaricus Mushroom-Enriched Diets Modulate the Microbiota-Gut-Brain Axis and Reduce Brain Oxidative Stress in Mice

1
Oncology Area, Center for Biomedical Research of La Rioja (CIBIR), 26006 Logroño, Spain
2
Centro Tecnológico de Investigación del Champiñón de La Rioja (CTICH), 26560 Autol, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Stanley Omaye
Antioxidants 2022, 11(4), 695; https://doi.org/10.3390/antiox11040695
Received: 10 March 2022 / Revised: 28 March 2022 / Accepted: 29 March 2022 / Published: 31 March 2022
Neurodegenerative diseases pose a major problem for developed countries, and stress has been identified as one of the main risk factors in the development of these disorders. Here, we have examined the protective properties against brain oxidative stress of two diets supplemented with 5% (w/w) of Agaricus bisporus (white button mushroom) or Agaricus bisporus brunnescens (Portobello mushroom) in mice. These diets did not modify the weight gain of the animals when compared to those fed with a regular diet, even after feeding on them for 15 weeks. The long-term modification of the microbiota after 12 weeks on the diets was investigated. At the phylum level, there was a large increase of Verrucomicrobia and a reduction of Cyanobacteria associated with the mushroom diets. No changes were observed in the Firmicutes/Bacteroidetes ratio, whose stability is a marker for a healthy diet. At the family level, three groups presented significant variations. These included Akkermansiaceae and Tannerellaceae, which significantly increased with both diets; and Prevotellaceae, which significantly decreased with both diets. These bacteria participate in the generation of microbiota-derived short-chain fatty acids (SCFAs) and provide a link between the microbiota and the brain. Mice subjected to restraint stress showed an upregulation of Il-6, Nox-2, and Hmox-1 expression; a reduction in the enzymatic activities of catalase and superoxide dismutase; and an increase in lipid peroxidation in their brains. All these parameters were significantly prevented by feeding for 3 weeks on the Agaricus-supplemented diets. In summary, the supplementation of a healthy diet with Agaricus mushrooms may significantly contribute to prevent neurodegenerative diseases in the general population. View Full-Text
Keywords: microbiota-gut-brain axis; neurodegenerative diseases; brain oxidative stress; Agaricus-supplemented diets; antioxidant activities; lipid peroxidation microbiota-gut-brain axis; neurodegenerative diseases; brain oxidative stress; Agaricus-supplemented diets; antioxidant activities; lipid peroxidation
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MDPI and ACS Style

García-Sanmartín, J.; Bobadilla, M.; Mirpuri, E.; Grifoll, V.; Pérez-Clavijo, M.; Martínez, A. Agaricus Mushroom-Enriched Diets Modulate the Microbiota-Gut-Brain Axis and Reduce Brain Oxidative Stress in Mice. Antioxidants 2022, 11, 695. https://doi.org/10.3390/antiox11040695

AMA Style

García-Sanmartín J, Bobadilla M, Mirpuri E, Grifoll V, Pérez-Clavijo M, Martínez A. Agaricus Mushroom-Enriched Diets Modulate the Microbiota-Gut-Brain Axis and Reduce Brain Oxidative Stress in Mice. Antioxidants. 2022; 11(4):695. https://doi.org/10.3390/antiox11040695

Chicago/Turabian Style

García-Sanmartín, Josune, Miriam Bobadilla, Eduardo Mirpuri, Vanessa Grifoll, Margarita Pérez-Clavijo, and Alfredo Martínez. 2022. "Agaricus Mushroom-Enriched Diets Modulate the Microbiota-Gut-Brain Axis and Reduce Brain Oxidative Stress in Mice" Antioxidants 11, no. 4: 695. https://doi.org/10.3390/antiox11040695

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